Abstract
Background: #Ceramic-on-ceramic (CoC) bearings have been in use
in total #hipreplacement (THR) for more than 40 years, with excellent
long-term survivorship but concerns over the ceramic-on-ceramic bearings
wear persist.There are few studies where they analysed the
ceramic-on-ceramic #implants retrieved. We wanted to investigate the wear
patterns and the surface properties of the CoC first generation THR
implants removed.
Case description: We have analysed two cases of ceramic head
on ceramic liner of Autophor primary THA implanted in active patients
and
retrieved for aseptic loosening after 34 and 31 years of well
function.The sphericity, surface roughness and #microtopography was
assess by a
profilometer and a white light interferometer. Scanning #electronmicroscopy of the implant-retrieved surfaces was also perform.
Abstract
Chronic inflammatory conditions like #RheumatoidArthritis (RA) causes
deposition of #Amyloid Associated (AA) in various tissues or organs
resulting in secondary or reactive systemic amyloidosis. We have
reported here a 58-year old lady, known case of RA since 17 years with
very
poor compliance to treatment who presented with #chronicdiarrhea since 2
months, on evaluation, upper GI #endoscopy and #biopsy revealed
positive for #serumamyloid associated on #innumohistochemistry staining,
suggestive of secondary systemic amyloiosis. Symptoms gradually
disappeared with the prompt institution disease modifying #anti-rheumaticdrugs (DMARDs). GI amyloidosis has been reported up to 60% of
the patients with secondary amyloidosis and must not be forgotten while
evaluating the cause for chronic diarrhea in a patient with #chronicinflammatorycondition like RA.
Abstract
#Environmentalpollution is the main vital troubles of the
society. Growth in #farming, energy sources and all #hazardouswaste producing industries is essential in categorize to execute the
requirements and burden of the increasing population. Individual
activities for the creation and development of supplies and services
can’t be extremely blocked as it is desirable by humans for the
endurance on world. For the times of yore, creation of dyes and stains
was augmented in the populated world. This concern is not only
because of #textileindustry but also from other industries like paper
and pulp, leather, food, #cosmetics etc. These production industries
are main regulars of water and consequently put strong foundation
to water pollution. Among these industries textile industries is
one of the supreme originators of water pollution owing to huge
quantity of water utilized during the process in dyeing plant. For
insistence yearly generation of dyes is approximately 7x105 tonnes
worldwide Allen and Koumanova [1]. Without proper treatment if
the dyeing effluent is disposed in the #waterbodies it leads to severe
issues to environment as well as to the humans.
Abstract
#Dentalresorptions, conditions in which mineralized #dentaltissues are eliminated by clastic #cells on their surface, persist as a
treatment challenge for dentists. Although the causes and mechanism
of its occurrence are known, many doubts have been observed in
its handling, which motivated the making of this article. Dental
resorptions in permanent teeth are pathological and, according to
their mechanism of occurrence, can be classified as inflammatory
and substitutive [1-3]. Clinically, they are asymptomatic and do not
induce #pulpal, periapical, and periodontal changes, and is usually
the consequence of them [4]. The inflammatory tooth resorption
occurs when the #cementoblasts are removed from the root surface,
resulting in a bare dental surface that allows the installation of
clasts units, associated with an inflammatory process induced by
the aggressor agent [3,4]. The causes may be multiple, especially
pulp #necrosis, excessive orthodontic forces and #alveolodentarytrauma. The factors may or may not be associated [1-3].
Abstract
Objective: There is limited information about the value of exercise
#echocardiography for the prediction of events after #coronaryartery
by-pass #surgery (CABS). Ischemia might be considered of limited value in
patients already revascularized by surgery. We sought to investigate
the value of exercise echocardiography (ExE) for the prediction of major
cardiac events (MACE) and overall mortality in patients submitted to
CABS.
Methods: Retrospective analysis of prospectively collected
data on 568 CABS patients (mean age 66±10 years) who were submitted to a
clinically indicated first treadmill ExE. Normal ExE was defined as the
absence of wall motion abnormalities (WMAs) at rest and at exercise.
Ischemia was defined as the appearance of new WMAs or the worsening of
resting WMAs. Abnormal ExE was defined as #ischemia or the
presence of resting WMAs unchanged with exercise. The end points were
MACE and overall #mortality.
Purpose: This study aimed to analyze the inheritance pattern of
infantile #esotropia and to investigate the possible involvement of AHI1
gene.
Methods: The experimental group consisted of 14 neurologically
normal patients with onset of large angle esotropia prior to 6 months
of age. Three unaffected subjects from a family of twins with esotropia
formed the familial control group. The main control group consisted of
11 organ donors with no history of #strabismus. Familial pedigree charts
allowed assessing transmission of strabismus phenotype up to four
generations. Genomic DNA was obtained from #peripheralblood and PCR
amplification of AHI1 gene was performed.
Results: The mean onset of esotropia was 1.78±2.32 months and
the mean deviation was 57±8.5 prims diopters. Amplification of AHI1
was observed in all patients in the control group, but not in those with
infantile esotropia. Among the patients evaluated, 57% had a family
history of strabismus. Genetic inheritance was observed in two families
with #monozygotic twins, one of them consisted of monozygotic twins
with infantile esotropia and a third #dizygotic twin without strabismus.
AHI1 did not amplify in the 3 unaffected subjects from the triplets’
family
that formed the familial control group.
Abstract
#Hyperbilirubinemia is one of the most commonly encountered conditions
even in otherwise healthy newborn infants in the first week
of life. There is emerging evidence that #polymorphism of genes involved
in #bilirubinconjugation such as the #UDP-glucuronosyltransferase
1A1 (UGT1A1) may contribute to some infants developing neonatal
jaundice, significant enough to require phototherapy. In many parts
of the world, glucose-6-phosphate dehydrogenase (G6PD) deficiency is
also a major cause of severe neonatal hyperbilirubinemia. Some
genetic polymorphisms of UGT1A1 and G6PD are associated with more severe
hyperbilirubinemia. Recently, the c.-3279T>A mutation in the
Phenobarbital responsive enhancer module was reported to decrease UGT1A1
transcriptional activity and associated with more neonatal
jaundice. However, there are limited reports of co-inheritance of these
two #genevariants, whether this predisposes infants to greater risk for#phototherapy. We studied a total of 133 infants and our results indicate
that the occurrence of UGT1A1 allele c.-3279T>G was similar in G6PD
deficient infants whether or not they required phototherapy in the first
five days of life. Co-inheriting both the c.-3279T>G and G6PD
variants
in these #deficientinfants also did not significantly elevate the peak
#serumbilirubin in the first week.
Abstract
Inflammatory #boweldisease (IBD) is an auto-immune condition
characterized by chronic #gastrointestinalinflammation. The incidence of
#pediatricIBD, particularly the early onset disease subtypes, has been
increasing internationally. In contrast to later-onset IBD, recent
literature
indicates that early-onset (between 3 - 5 years) and very early-onset
(between 0 - 2 years) patients present with a more severe and #aggressivedisease. A comprehensive review of the literature indicates that the gut
microbiome, which is heavily influenced in the early life, is reduced
in
IBD patients and hence plays a role in regulating #gastrointestinalhomeostasis. While many genes have been confirmed to be associated with
IBD, only a portion of those genes have been shown to cause pediatric
IBD.
Abstract
#CysticFibrosis (CF) is a multisystem #geneticdisease whose main
cause of #morbidity and #mortality is progressive impairment of lung
function associated with loss of quality of life and functional
capacity. We report the clinical case of an 18-year-old adolescent
accompanied at
a reference center with #bronchialhyper-secretion, recurrent infections,
bacterial colonization, important obstructive ventilatory disorder, and
pulmonary #computedtomography (CT) showing a heterogeneous pattern. The
authors emphasize the importance of continuous monitoring of
#pulmonary, nutritional and functional parameters, allowing for more
effective early interventions.
Abstract
We present the case of a 14-year-old girl, who presented with a
positional #vertigo of second duration, compatible with BPPV, but whose
final #diagnosis was a #cavernoma in the #cerebellum. We emphasize the
importance of keeping in mind the different etiologies of #vestibularsyndrome in children.
In the face of a #gigantic technological evolution in the study,
#diagnosis and treatment of #cardiovascular diseases, they continue
to be responsible for high rates of mortality and #morbidity throughout the world. In this context, acute myocardial infarction
is a major #villain, abridging the active life of a growing population.
Even with technological advancement in means for the adequate
treatment of this #pathology, these means become obsolete
without measures to promote orientation of the population in
recognizing g their symptoms and seeking medical attention.
Manual preparation of drug concentration gradient is #labor-intensive and
limits the efficiency of a drug screening to some extent, especially
at large scale. In this study, we reported an automatic method to
generate drug concentration gradient in 24-well plate. We loaded drug
solution
in a modified hot #ink-jet printer, designed printing pattern in the WORD
software, customized the concentration gradient in the WORD software
by #RGB coding, and finally printed the drug concentration gradient in
the 24-well plate. A drug concentration gradient can be automatically
generated within 5s in arbitrary pattern. On the basis of this flexible
technology, we developed an ink-jet printer-based drug screening assay.
Concentration gradient of #5-fluorouracil, as well as Mcf-7 cells, was
printed in the 24-well plate, and the inhibition rate of #Mcf-7 cells was
measured by MTT method. This was the first time that hot inkjet printing
technology was used in drug screening.
This paper presents the effectiveness of #RAMPA (Right Angle Maxillary
Protraction Appliance) system, i.e. RAMPA combined
with ROA (RAMPA Oral Appliance), on human maxillae by analyzing the
#deformations from #protraction forces with finite element method. In
addition, the dimensional changes of the upper airway, skeletal facial
and #hyoid position changes by using cone-beam computed #tomography in
patients who were treated with RAMPA therapy were assessed clinically.
Study participants were women experiencing #dysmenorrhea monthly (for the
6 preceding months) at a level >5 on the
visual analog scale (0-10), who were otherwise healthy. The study
#participants also collected their #menstrual fluid for 2 baseline months,
while
recording their pain levels (primary outcome) systematically. A
correlation between menstrual fluid characteristics and menstrual pain
was
studied, too.
The enormous diversity of #microorganisms in the environment
offers an almost unlimited gene pool for new enzymes and metabolic
pathways. The discovery of new natural products continues to be of
great interested for the production of #pharmaceuticals. An exciting
approach to generating new products is to evolve novel metabolic
pathways in a microbial cell by means of the technique of metabolic
engineering. Cell culture is playing an increasingly more significant
role in drug discovery. Animal cell biotechnology constitutes an
important field in #Biotechnology nowadays. Animal cells produce
many biological of great value involving enzymes, hormones,
growth factors, viral vaccines, or #monoclonal antibodies, and many
therapeutic proteins require #post-translational modifications
which can be only fully performed by animal cells. Insect virus,
immune-regulators or whole cells, which are used for toxicological
testing, can be obtained from animal.
Abstract
Burnout is a #psychologicalresponse to exposure to chronic stressors
at work and is characterised by high levels of #emotionalexhaustion,
#depersonalisation and reduced personal accomplishment. Expression of
burnout is said to be mediated by internal and external factors that
act in predisposing, precipitating, perpetuating and protective roles.
Active screening for burnout in employees using affective, cognitive,
#behavioural and motivational signals helps raise awareness and ensure
prompt intervention is offered. Systematic reviews have identified the
significance of combining individual and organisational intervention
strategies which appear to work best if intensive and booster sessions
are
offered in conjunction.
Abstract
In order to find the best planting pattern of soybean (#Glycine max L. Merill) with #sorghum (Sorghum bicolor
L.) intercropping, this research
performed in Gorgan and Aliabaad. Experiment compared on three levels
inform of pure sorghum with density of 250000 plant per hectare,
#intercropping of sorghum and soybean with density of 250000 and 400000
plant per hectare, respectively and intercropping of sorghum and
soybean with density of 300000 and 480000 plant per hectare,
respectively. The number of planting lines was 60 liens with length of
66.66
meters and 50cm interval. For measuring of plant height, number of
tiller, stem diameter and number of node, 10 bushes randomly harvested
by using quadrate. By the way total surface area based of project
protocol also #harvested. For the results analysis t-test applied. Fresh
forage
production at treatment of intercropping with 300000 and 480000 plant
density for sorghum and #soybean, respectively in Gorgan %33.33
and in Aliabad %34.32 had priority compared to check treatment (sole
cropping of sorghum with density of 250000 plants per hectare). Mean
comparison of dry forage also indicated %24.01 increasing in Gorgan and
%26.12 in Aliabaad.
Abstract
#Discalcysts are uncommon causes of low back #pain and radiculopathy.
Due to the diversity of discal cysts was reported by about 50 case
reports; we do not yet have a detailed understanding of their natural
history, #etiology or pathogenesis. Here, we report two unique discal
cysts
to give a new insight to our understanding of the #pathogenesis of discal
cysts.
Abstract
Layer of protection analysis (LOPA) was conducted on #toxic and
#flammable hazard of #sterilization process using #ethyleneoxide. Hazard
associated with the process were studied using HAZOP and scenarios were
developed by applying the HAZOP result. For each scenario,
independent protection layers (IPLs) were identified and their
frequencies were estimated. Three additional IPLs were considered such
as
personal protection equipment, monitoring device, and #ventilation
window. By adding such IPLs, the risk was estimated to be reduced to
less
than chances per million.
Abstract
Objective: It was to investigate the relationship between high-TSH degree and changes of LDL-C level in pregnant patients’ #serum and take
analysis of its influencing effects.
Methods: All subjects were collected from the Yancheng First
People’s Hospital from January 2014 to December 2015, who was diagnosed
by the #Endocrinology Department. Then it analyzed their #biochemicalindicators and blood liquid parameters in their serum. Additionally, we
investigated their epidemiological data, including the disease history
and #genes. At last it took regression analysis of its relevance.
Results: High-TSH degree and changes of LDL-C level are risk
factors leading to #hypertension, #cardiovascularsymptoms, symptoms of
digestive tract, pregnancy #ultrasound indicating small-sized fetus and
they are related to one another (P<0.05); Whereas it has nothing to
do
with gestational diabetes mellitus, preterm birth history and #autoimmunediseases. In the whole, high-TSH degree group, the high cholesterol
could cause premature birth, elevated blood sugar, high blood pressure
prenatal, #postpartum infection and #preeclampsia (P<0.05)
Abstract
At room temperature, the protective efficacy of the #volatileinhibitors (VIC) “IFHAN-A” (A-112, 114 and 118) was studied under
#atmosphericcorrosion of carbon steel St3, brass L62 and copper M2 in the presence
of #corrosionstimulants (CS) in the air: CO2 ((0.2-0.6) vol. %); H2S ((10-
30) mg /m3); NH3 ((20-60) mg /m3) and 100% relative #humidity, which simulates the atmosphere of livestock buildings. In the case of #carbonsteel in the presence of a binary mixture of CSs: CO2 + NH3, CO2 + H2S and NH3 + H2S,
the protective action of the VIC is between 67 and 95%.
When #corrosion of brass and #copper, the protective capacity of IFHAN-112
and IFHAN-118 decreases accordingly to 10 (Cu, IFHAN-112, NH3 +
H2S) and 13 (brass, IFHAN-118, СО2 + H2S) % or 30% (brass, IFHAN-118, NH3 + H2S). These VIC stimulate copper corrosion in the presence of a
binary mixture (CO2 + H2S). Only in the presence of IFHAN-114, the protective effect does not decrease below 74%.
Abstract
The #localanesthetics are widely u sed in minor #pediatricsurgicalprocedures. The major problem with their use is the resulted pain
experienced by the patients at the time of #injection. To discuss those
situations in the light of the medical literature we present this
mini-review.
Abstract
#Nanobio-MOF compounds 3-5 (#copperserinate, copper prolinate and
copper threoninate) have been evaluated for successful in vitro drugs
adsorption of three drugs, named #terazosine, #telmisartan and #glimpiride.
Pore sizes and BET surface areas were recorded on N2 adsorption
isotherms. In order to elaborate the phenomenon of #invitro drugs
adsorption in all these compounds we obtained TGA and PXRD spectra of
them. The high performance liquid #chromatography (HPLC) was used to
monitor the amounts of adsorbed #drugs and its slow release from all
these compounds.
Abstract
Three types of #tissue-engineered products were developed using cell,
growth factor, and #biomaterial. The first product is a CDS composed
of allogeneic fibroblasts combined with a HA and Col spongy sheet. #Fibroblast can release various growth factors that are essential for
wound
healing. HA and Col have a potential to enhance #woundhealing. This CDS
can be #cryopreserved for a long period of up to clinical use. The
clinical
study demonstated that #allogeneic CDS is a useful product. The second
product is a wound dressing composed of HA and Col containing EGF.
EGF has a #potential to enhace wound healing. This wound dressing is a
freeze-dried spongy sheet, thereby the efficacy of EGF can be kept for
a long period of up to clinical use. The clinical study showed that
EGF-incorporating wound dressing is a practical product. The third
product
is an anti-adhesive #spongysheet composed of HA and Col containing EGF.
This is also a #freeze-driedspongy sheet. The animal study indicated
that EGF-incorporating anti-adhesive spongy sheet is a promissing
product.
Abstract
Commercialization of algal-based processes for #biofuels and
#co-products is constrained upstream during #cultivation by low
productivity, contamination by invasive species, unsustainable and
inefficient supply of nutrients (e.g. #nitrogen and #phosphorous),
#inorganiccarbon, and water, exposure to environmental factors, and
limited available land acreage for inoculum and primary cultures. It
is also constrained downstream by costly and inefficient harvesting,
product extraction, #thermochemicalconversion, #hydrotreatment,
and upgrading. Overcoming these obstacles to commercialization
requires not just piecemeal incremental improvements, but rather
a comprehensive and fundamental re-consideration regarding the
selected algae and its associated cultivation, #harvesting, biomass
conversion, and refinement. Factors pertaining to algal-strain
selection for commercial operations are presented below.
