Journals on Emergency Medicine - BJSTR Journal

Abstract

#Tricyclic carbazole nucleus is an integral part of naturally occurring alkaloids and synthetic derivatives, possessing various potential biological activities such as anticancer, antimicrobial and antiviral. Binding mechanism of #carbazole with target receptor as molecule or fused molecule exhibit potential lethal effect. In the present work, development of microwave assisted organic synthesis (MAOS) methods for synthesis of a novel series of N-Mannich bases of carbazole annulled with substituted benzothiazole-2-amine with carbazole (secondary aromatic amine) and #aldehyde derivatives has been presented. All the synthesized compounds were characterized by #physicochemical and spectral methods viz. ultra-violet, FT-IR, 1H-NMR, Mass and elemental analysis. The newly developed MAOS method evident the improvement in percentage yield (% yield) and reaction time compared to conventional method. The synthesized compounds were screened for antibacterial (#B. subtilis, S. aureus, E. coli and #P. aeruginosa) and antifungal activities (#A. niger and #C. albicans) using impregnated paper-disc diffusion method. 

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Synthesis and Pharmacological Evaluation of Tricyclic Carbazole Annulated with Substituted Benzothiazole-2-Amine Under Microwave Irradiation by Atul Sharma in BJSTR