Medical and Medicinal Journal - BJSTR Journal

Abstract

#Renal glucosuria (RG) is a disorder of #proximal tubular glucose transport, characterized by abnormal urinary excretion of glucose in the absence of impaired glucose metabolism. In some affected families, RG is caused by #homozygosity or compound #heterozygosity of mutations in the SCL5A2 gene, encoding the renal-specific sodium/glucose cotransporter 2. Some children are detected as urine glucose positive with no evidence of #hyperglycemia in a screening program at school, and are diagnosed as having RG. We found about 30% of Japanese school students with a positive result at a urine glucose screening program at school was diagnosed with diabetes. On the other hand, the others, almost 70% of cases, with positive urine glucose was finally identified as having RG with no evidence of glucose intolerance in the detailed examination. They had a strong family history of RG. We conclude that RG may be not rare, but a frequent condition with #glucosuria among Japanese school children.

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Renal Glucosuria-Most Frequent Condition with Positive Urine Glucose in A Screening Program at School by Tatsuhiko Urakami in BJSTR