Journals on Medical Research - BJSTR Journal

Abstract

Background: #Neuropeptides can be influenced by #psychophysical stress and may have influence on #cardiac function.

Objective: We wanted to find out, whether pro- and #anti-inflammatory neuropeptides may be altered in #heart failure (HF) and may be modulated by #psychophysical stress.

Methods: Therefore, 29 patients of both gender suffering form heart failure (NYHA II-III) or and 20 healthy volunteers were investigated for the levels of the #pro-inflammatory neuropeptides TNFα, IL-6, IL-2, IL-1β and IL-12, and of the anti-inflammatory neuropeptides GHrelin, urocortin, #adrenomedullin and VIP as well as for TH1, TH2, TH17, CD4 and CD4CD25 cells. Left ventricular (LV) ejection fraction (LVEF), end-diastolic and end-systolic diameter (LVEDD; LVESD) were assessed #echocardiographically. Psychophysical stress and quality of life was evaluated by the SF-36 questionnaire.

Results: In NYHA II- and III-patients #urocortin, #adrenomedullin and VIP were elevated, while Ghrelin, TNFα, IL-12 and IL-2 were unchanged. IL-6 was slightly elevated and IL-1β was slightly reduced in NYHA II. TH17 cells were reduced, while TH1, TH2 and CD4 were unchanged. CD4CD25 were slightly increased. SF-36 questionnaire revealed nearly unchanged emotional and social functioning while the physical role functioning was reduced in HF-patients.

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Anti-Inflammatory and Pro-Inflammatory Neuropeptides in Dilative Cardiomyopathy are there Relations to Psychophysical Stress? by Norbert Klein in BJSTR

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