Journals on Emergency Medicine - BJSTR Journal

Abstract

For the last two decades the role of Vitamin D3 has been recognized not only as a regulatory component of a bone - kidney metabolism, but also as an important #immunomodulator [1]. Low serum levels of vitamin D are detected before an egzacebation in rheumatic diseases: psoriatic arthritis, rheumatoid arthritis and #ankylosing spondylitis [2,3]. Same has been shown in exacerbation of #Hashimoto's thyroiditis and ulcerative colitis, multiple sclerosis, in some kinds of cancer, in cardiovascular diseases and diabetes mellitus type 2 [4-8]. Also, low levels of vitamin D3 have been confirmed many years before onset of autoimmune disease [2,9].Recent studies have investigated new role of vitamin D in intracellular processes. Dankers et al. [10] showed possible molecular mechanisms in which vitamin D can interphere intracellular mechanisms [10]. It is known that actions of vitamin D3 are mediated by the vitamin D receptor (VDR), a ligand-activated transcription factor that functions to control gene expression [11]. VDR protein is comprised of three regions, an N-terminal dual zinc finger #DNA binding domain, a C-terminal #ligand-binding activity domain and an extensive region that links the two functional domains of this protein together [12].

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Vitamin D3 as a Powerful Immunoregulator - Cause or Consequence of Disbalance? by Miskic B in BJSTR