Journals on Regenerative Medicine - BJSTR Journal

Abstract

Soft tissue sarcomas are exceedingly rare tumors that account for 1% of all human #malignancies. More than 50 #histologic subtypes of STS are recognized. Limb salvage surgery and radiation (RT) are the standard of care in management of extremity #sarcomas [1]. The timing of RT; whether preoperative or postoperative, has been tested in a prospective trial [2], both approaches have comparable #oncologic outcomes in terms of local control and survival. However, preoperative RT was found to have a higher risk of major wound complications. On the contrary, late side effects such as fibrosis, joint stiffness and edema were more prevalent in patients receiving postoperative RT [3]. Soft tissue sarcoma volume usually changes after #neoadjuvant RT. Many physicians perceive this response as a sign for disease response and treatment outcome. However, this suggestion was not studied nor proven. Another surrogate is post-treatment tumor necrosis; the effect of histologic response on disease outcome is not well defined and data are conflicting.Nevertheless, some studies have reported better survival with near complete necrosis [4]. Furthermore, it is unknown if #radiologic response does correlate with #pathologic response in the surgical specimen following neoadjuvant RT.

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Correlation of Radiologic and Pathologic Response in Patients Receiving Neoadjuvant Radiotherapy for Soft Tissue Sarcoma by Ramiz Abu Hijlih in BJSTR