Abstract
#PABA is a well-known water-soluble vitamin H1 of group B (folic
acid). Its high genetic activity as an antimutagen and antioxidant agent
has proven in vivo and in vitro. The new scientific data on the
mutual PABA + NO application gave rise to some amazing results. Complex
PABA/NO is a nitric oxide-releasing agent which selectively activated in
cancer cells to over express GSTP1. PABA/NO was efficient in some
cancer models in vivo and in vitro. PABA/NO is a promising prodrug in medicine.#Para-aminobenzoic acid (PABA) - Vitamin H1 of group B and a key cofactor
for the folic acid production in bacteria [1] has obtained fundamental
and practical interest as a unique water- soluble natural #antimutagen since 1979 [2-4]. A priority data obtained by Russian geneticist Josef
Rapoport in the 1950-th have revealed the morphogenic effects of PABA in
#Drosophila. Then investigations of the different test objects led to
the detailed research of the amazing PABA activities. Firstly, in the
experiments with the potent chemical mutagens - #alkylating agents, UV-
and gamma irradiation S Vasilieva et al. [5]
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