Tuesday, November 5, 2024

Hormonal Disorders in Adolescents with Hypogonadotropic Hypogonadism in Kashkadarya Region of Uzbekistan

 

Hormonal Disorders in Adolescents with Hypogonadotropic Hypogonadism in Kashkadarya Region of Uzbekistan

Background

Negative medical and demographic trends, which are noted in the past 15 years in the CIS, are closely interrelated with progressive deterioration in the reproductive health of the population [1-4]. As is known, the delay in sexual development or pubertata implies the lack of an increase in the testicular volume (<4 ml) and if the length of the testicles does not reach 2.5 cm (<4 ml) at the age of 15 [5]. In accordance with the ICD-10, the delay of sexual development is highlighted as an independent endocrine disease. PD (Puberty delay, or somatosexual development) is one of the actual problems of endocrinology, andrology and sexopathology, attracting the attention of specialists from various centers. According to various authors, the frequency of the PD ranges from 0.4% to 9.8%, and over the past decades it is noted [6,7]. The differential diagnosis of the isolated deficiency of gonadotropic hormones and the constitutional delay of sexual development is the necessary and difficult task in the daily work of the endocrinologist. Since the clinical picture with these states is similar, it is quite difficult to distinguish them. Therefore, the study of the hormonal profile is an urgent diagnostic procedure [5].

For an isolated shortage of gonadotropic hormones, a normal growth and normal growth rate is characterized, and for the constitutional delay of sexual development is characterized by lowness. In both states, the basal levels of LH and FSH are reduced, and the levels of other pituitary hormones are within the normal range. Therefore, ordinary hormonal studies and sample with gonadoliberin are not given anything for a diagnosis. With a constitutional delay in sexual development, the basal level of prolactin is normal or slightly reduced and significantly increases after the administration of Tyrolyberin. In the majority of patients with an isolated shortage of gonadotropic hormones, the basal level of prolactin is low and does not increase either slightly increase after stimulation by Tyrolyiberin [8]. Hypogonadism, in contrast to the delay of sexual development, which can be viewed as a border state, is a disease with a serious disorder of the functioning of the entire reproductive system requiring a long (sometimes constant) hormonal therapy.

Often, parents (sometimes children themselves) are addressed to the doctors - pediatricians, therapists, urologists, endocrinologists (sometimes children) with complaints about the lagging in the development of genital organs regarding peers. Some of these patients are sent to the consultation by other specialists. In about 90% of cases, as a result of the survey, it turns out that the delay in sexual development in a child (adolescent, young men) is absent. However, the overwhelming majority of doctors in solving these issues only focus on the subjective perception of the somatic status of the patient and their practical experience. Meanwhile, it is necessary to objectify anamnesis, inspection, the results of a laboratory survey to obtain reliable results regardless of personal experience and the subjective opinion of the doctor. All the above appeared the basis for this study.

The Purpose of the Study

The purpose of the study is to study hormonal disorders in adolescents (boys)with hypogonadotropic hypogonadism in sexual development stages. Material and research methods. 523 pupils of schools of Nukus and 4 districts had detailed examination of 143 adolescents aged from 11 to 16 years have been examined. From the examined patients, we found 106 (20.3%) adolescents aged 11-16 years, suffering from the delay of pubertate to varying degrees. All 106 patients were performed by a study spectrum, which included the study of endocrine status, generally clinical, biochemical, hormonal (STS, LH, FSH, Prolactin, TSH, testosterone, cortisol, free thyroxine, etc.), in addition, anthropometric studies were performed to all adolescents (target height, centile, growth rate, SDS growth and weight, etc.) based on the international growth-weight map of Tanner-Weithaus, estimates of the penal development stage on a tanner (using tables and an orchidometer), if necessary - X-ray (radiograph of brush and Turkish saddle , radiography brushes, ultrasound of the thyroid gland and genital organs. The data of control of the appropriate age and gender for hormonal studies were provided by the Hormonal Research Laboratory of the Center of Endocrinology of PHM of RUz. The data obtained was processed using Microsoft Excel and Statistica_6 computer programs. The differences between the groups were considered statistically significant at Р< 0.05. The average values (m) were calculated, standard deviations of medium (M).

Results

Table 1 is given the distribution of patients by age. As can be seen from Table 1, most often among the examined patients aged 13.2 ± 0.8 years and 15.5 ± 0.7 years (36.7% and 30.1%) were met. Table 2 shows the average values of various hormones in patients with PD in sexual development stages. Table 2 it follows that in all age-related periods of sexual development, the surveyed patients had hypogonadotropic hypogonadism (HH): a significant decrease in the average levels of LH, FSH, a total testosterone - from (p <0.05) was noted. In this case, the lowest these values were in patients with 2 Puberty stages, that is, aged 11.7 ± 1.3 years (n = 17) on the background of normoprolactinemia. The average levels of prolactin were not reliably elevated in patients 3 and 5 of the stages of the Tanner (P> 0.05). It should be emphasized that the levels of STHs, TSH and free thyroxine, as well as cortisol, were within the norm in all patients (N = 106). When comparing the stages of pubertate and hormonal data, it was revealed that as the ages increases, the average values of LH, FSH, a common testosterone, although they remain reliably reduced. Next, we analyzed cases of the lowest values of LH, FSH and the total testosterone, namely, when the LH/ FSH levels ranged from 0.1 to 0.9 IU/L, from - from 1 to 3 nmol / l (severe degree of HH) , cases of average gonadotropin values and from when the levels of LH/FSH were ranging from 1 to 4 IU/L, from - from 3 to 7 nmol / l (average severity of the HH), as well as cases with a slight degree of GG, when levels LH/FSH ranged from 4 and above, from - from 7 nmol/ l and higher (easy severity of HH).

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Table 1: The distribution of patients by age. (5 Tanner Stages).

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Table 2: Average values of hormones in patients according 5 Tanner stages.

Note: Р – The accuracy of differences compared to the control group. In the table for comparison, there are vibrations of hormone levels from 11 to 16 years of control group (healthy faces).

Thus, this characteristic allowed us to highlight 3 groups of patients with 3 degrees of gravity HH - moderately, medium and heavy - depending on the mean values of LH, FSH, from. These data are shown in Tables 3-5. Table 3 shows the number of patients with a severe degree of Tanner’s stages. The total number of these patients turned out to be -39 (36.7%). As can be seen from the data in Table 3, when analyzing the lowest values of LH, FSH and the total testosterone, namely, when the LH / FSH levels ranged from 0.1 to 0.9 IU / L, from - from 1 to 3 nmol / l (severe degree of HH) The total number of cases was equal to 17 (16.04%). In this group, the reliability of differences was the highest (p <0.05). Table 4 shows the number of patients with the average degree of Tanner’s stages. The total number of these patients turned out to be 77 (72.6%). When analyzing the cases of moderate severity of the HH, we proceeded from those mean values of gonadotropins and from when the levels of LH/FSH were ranging from 1 to 4 m/ l, from - from 3 to 7 nmol/ l (average severity of the HH). In total, such cases turned out to be 77 (72.6%) and this group was dominant (p <0.05, as well as p> 0.05).

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Table 3: The number of patients with a severe degree of HH, depending on the mean values of the LH, FSH and from the patients on 5 Tanner stages.

Note: FT- Free Testosterone., P is the accuracy of differences compared with control (1).

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Table 4: The number of patients with the average severity of the HH, depending on the mean values of the LH, FSH and from the patients with 5 Tanner stages).

Note: FT- Free Testosterone., P is the accuracy of differences compared with control (1)

Table 5 is given the number of patients with a slight degree of HH in Tanner Stages. The total number of these patients turned out to be 12 (11.3%). Cases with a light degree of HH, when the LH / FSH levels were fluidated from 4 and above, from - from 7 nmol / l and above (an easy severity of HH) amounted to 12 patients (11.3%). In this group of patients, the reliability of differences in the content of LH, FSH, from plasma was less reliable, while in the range from p <0.05 to p> 0.05. Thus, the analysis of hormonal results showed that the average severity of the HH (72.6%) was most often observed, while less frequently met (16.04%) and light (11.3%) of its degree. Only 1 (0.9%) of the patient identified hypergronadotropic hypogonadism.

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Table 5: The number of patients with a slight degree of HH, depending on the average values of the LH, FSH and from. Patients in 5 Tanner Stages).

Note: FT- Free Testosterone., P is the accuracy of differences compared with control (1)

Conclusion

1. In all age-related periods of sexual development, hypogonadotropic hypogonadism took place in the surveyed patients: a significant decrease in the average levels of LH, FSH, a total testosterone (p <0.05) was noted. Only 1 (0.9%) of the patient identified hypergronadotropic hypogonadism.

2. When comparing the stages of pubertate and hormonal data, it was revealed that as the ages increases, the average values of LH, FSH, the total testosterone, although they remain reliably reduced.

3. There are 3 severities of hypogonadotropic hypogonadism: light (11.3%), average (16.04%) and heavy (72.6%).

4. This category of patients’ needs further examination (magnetic resonance imaging of pituitary glands, ultrasound genital organs, etc.) and treatment [5].


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Monday, November 4, 2024

Prevalence of Bovine Trypanosomosis in and Around Sadi Chanka District, Western Oromia

 

Prevalence of Bovine Trypanosomosis in and Around Sadi Chanka District, Western Oromia

Introduction

Livestock production constitutes one of the principal means of achieving improved living standards in many regions of the developing world. In sub-Saharan Africa countries livestock plays a crucial role both for the national economy and the livelihood of rural communities. Ethiopia takes the lead in livestock population in Africa, with an estimated 53.99 million cattle population [1]. Livestock fulfill several functions in the Ethiopian economy by providing food, traction power, cash income, fuel and organic fertilizer. Livestock is also an important provider of export commodities such as live animals, meat, hides and skins and over the past few years, livestock and its products has been Ethiopia’s second most important source of export, after coffee [2]. However, poor health and productivity of animal due to disease has considerably become the major stumbling block to the potential of livestock industry [3]. Animal diseases in general and infectious ones in particular are the major constrains to crop and livestock production in the humid and sub humid parts of the African continent.

Parasitic diseases especially animal trypanosomosis is the most important factor contributing to the sub potential performance of livestock; 10 million heads of cattle and equivalent numbers of small ruminants together with significant equine and camel population are at risk of contracting the disease any time. The disease is a serious often fatal disease of mainly domestic animals that occur in large areas of Africa. It is caused by species of flagellate protozoa belonging to the genus Trypanosoma of the family Trypanosomatidae that multiply and inhabit in the blood stream, lymphatic vessels and tissue including the cardiac muscle, and central nervous system (CNS) of host, and are transmitted by vectors which are generally haematophagus arthropods (Fischer and Say, 1989). Most cases of animal trypanosomosis (Nagana) are transmitted cyclically by tsetse flies of genus Glossina [4]. Trypanosomosis is the most serious veterinary and animal production problem in sub Saharan Africa and prevents the keeping of ruminants and equines over 10 millions of square kilometers of potentially productive land.

Hence, this study is the road map and contribution to the Pan African Tsetse and Trypanosomosis Eradication Campaign agenda [5]. Trypanosomosis is the most important constraint to livestock and mixed crop-livestock farming in tropical Africa. Currently about3 million livestock die every year due to tsetse fly transmitted the disease which covers one third of the continent estimated to be 10 million km2. A recent study estimated the direct annual cost of the disease to be about 1.34 billion US$. African livestock producers are administering an estimated 35 million curative and prophylactic treatments annually which costs the producers and the government at least 35 million US$ Holmes, et al. [6]. In Ethiopia, a substantial amount of the national resource is spent annually for control of trypanosomosis through purchase of trypanocidal drugs. An annual loss attributed to the disease exceeds US $236 million, while loses from reduced milk and meat production and from animal draught power and manure are unquantifiable [7]. According to Getachew, et al. [8], trypanosomosis is prevalent in two main regions of Ethiopia that is, the North West and the South West regions.

Six species of trypanosomes are recorded in Ethiopia and the most important trypanosomes, in terms of economic loss in domestic livestock are the tsetse transmitted species: T. congolense, T. vivax and T. brucei. For the closely related T. brucei subspecies, T. b. rhodensiense, which causes human sleeping sickness, cattle can be a reservoir host. The other trypanosome species of economic importance are Trypanosoma evansi of camels and Trypanosoma equiperdum of horses [9]. According to NTTICC [10], tsetse transmitted animal trypanosomosis still remains as one of the largest causes of livestock production losses in Ethiopia. About 10 to 15% of the land believed to be suitable for livestock production is affected by one or two species of the tsetse flies. While tsetseborne trypanosomosis is excluding agriculturally suitable land of the country; 14 million head of cattle are at the risk of contracting trypanosomosis at any one time [11,12]. A number of studies have been so far undertaken in different parts of Ethiopia to determine the magnitude of this economically important disease [13,14]. Nevertheless, very few and limited studies were carried out to assess the prevalence of this disease in Sadi Chanka District. Thus, the objective of this study was to determine the prevalence of bovine trypanosomosis and to identify the prevailing species of trypanosomes and to assess host related risk factors in Sadi Chanka District, Kellem Wollega zone, Oromia Regional State of Ethiopia.

Materials and Methods

Study Area

The study was carried out in Oromia Regional State, Kellem Wellega zone, in Sadi Chanka district which is located at 80 km away from Addis Ababa towards the west part of Ethiopia. The major town of Sadi Chanka district is Chanka. Sadi Chanka has a tropical climate and the city remains mostly hot and humid throughout the year. The winter season lasts from December to February and the average temperature during the winter months is around 30 degrees Celsius. Normally the summer months of Sadi Chanka are very cold and the average temperature is around 15 degrees Celsius. However, the temperature may rise up to 38 degrees Celsius on a hot winter day. The area receives an average annual rainfall of 1200 to 1800 mm [10]. The total human population of this area is 116170. Out of this total population of 116170 inhabitants, around 55378 were recorded as males and the remaining 60792 were females. Sadi chanka is also a major producer of coffee and more than 300,000 kilos of coffee beans and many other products like Maize and animal skins are exported annually. Moreover, many new mining factories and industries are being introduced in the town making it an important commercial center in Ethiopia. The district covers an area of 32,573.571 hectares and it is bordered by Dale Sadi at east, Hawa Galan at west, Dalle Wabara at north and at northeast and Ilu Abbaa bor at South [10].

Study Animals

The study animals were cattle of both sexes and different age groups (young and adult) in and around Sadi Chanka district which kept under extensive management system were randomly selected.

Study Design

Cross-sectional study was conducted in Sadi Chanka district, Kellem Wollega zone, Western Ethiopia in dry season from December 2020 to June 2021 to determine the prevalence of bovine trypanosomosis, to identify the prevailing species of trypanosomes and to assess host related risk factors.

Sample Size Determination and Sampling Method

The sample size was calculated according to the formula given by Thrusfield [15] with 50% expected prevalence (considering that no previous study has been done in the area), 95% confidence level and 5% precision. Simple random sampling technique was followed to select individual animals. During sampling, species, age, sex and body condition of the animals will be recorded. Body condition for each cattle will be estimated based on Nicholson and Butterworth (1986) ranging from score 1 (emaciated) to 5 (obese). Though, the required sample size was computed to be 426.

where, N= required sample size pex= expected prevalence, D= precision

Study Methods and Procedures

Direct methods usual field methods

i) Blood sampling Trypanosoma species is a parasite of the blood and tissues often inhabiting the deep blood vessels in cases of low parasitaemia. For this reason, it is recommended that blood for diagnosis be obtained from both the peripheral and deep blood vessels. However, it should be realized that less than 50% of infected animals may be identified by examination of peripheral blood. Peripheral blood is obtained by puncturing a small vein in the ear or tail. Deeper samples are taken from a larger vein by syringe. Cleanse an area of the ear margin or tip of the tail with alcohol and, when dry, puncture a vein with a suitable instrument. Ensure that instruments are sterilised or disposable instruments are used between individual animals, so that infection cannot be transmitted by residual blood. ii) Wet blood films Place a small drop of blood on to a clean glass slide and cover with a cover-slip to spread the blood as a monolayer of cells. Examine by light microscopy (×40) to detect any motile trypanosomes.

iii) Stained thick smears Place a large drop of blood on the centre of a microscope slide and spread with a toothpick or the corner of another slide so that an area of approximately 1.0–1.25 cm in diameter is covered. Air-dry for 1 hour or longer, while protecting the slide from insects. Stain the unfixed smear with Giemsa’s Stain (one drop of commercial Giemsa + 1 ml of phosphate buffered saline [PBS, 2.4 g Na2HPO4.2H2O, 0.54 g NaH2PO4.2H2O, 0.34 g NaCl], pH 7.2), for 25 minutes. After washing, examine the smears by light microscopy at high magnification (×100) oil imersion. The advantage of the thick smear technique is that it concentrates the drop of blood into a small area, and thus less time is required to detect the parasites. The disadvantage is that the trypanosomes may be damaged in the process, and the method is therefore not suited for species identification in case of mixed infections. iv) Stained thin smears Place a drop of blood 20 mm from one end of a clean microscope slide and draw out a thin film in the usual way. Air-dry briefly and fix in methyl alcohol for 2 minutes and allow drying. Stain the smears in Giemsa (one drop Giemsa + 1 ml PBS, pH 7.2) for 35 minutes. Pour off, stain and wash the slide in tap water and dry. Unfixed smears can be stained by covering them with May–Grünwald stain for 2 minutes, then adding an equal volume of PBS, pH 7.2, and leaving the slides for a further 3 minutes. Pour off and add diluted Giemsa for 25 minutes.

Pour off, wash the slides with tap water, and dry. Examine at high magnification (×40– 100x) oil imersion. This technique permits detailed morphological studies and identification of the trypanosome species. Rapid staining techniques also exist (Field’s stain, Diff Quick®). Data Analysis Collected raw data and results of parasitological and hematological examination was entered in to a Microsoft excel spread sheets program and then was transferred to SPSS version 21 for analysis. The prevalence of trypanosome infection was calculated as the number of positive animals as examined by Giemsa stain of thin blood film and buffy coat method divided by the total number of animals examined at the particular time. Pearson’s chi-square (χ2) was used to evaluate the association of different variables with the prevalence of trypanosome infection. P-value less than 0.05 at 95% level of confidence interval) were considered significant in all analysis.

Results

Parasitological Findings; Out of the total 426 cattle examined, 88 (20.6%) cattle were found positive. The prevalence was 22 (27.5%) in Midega Birbir, 28 (21.5%) in Keto 01 17 (23.9%) in keto 11, 12 (13.7%) in Keto 05 and 9 (14.2%) in Chanka town which has statistically significant difference observed between the implemented kebeles (P<0.05) (Table 1). There was not statistically significant difference observed between the two sex and age categories of animals (P>0.05). However, there was higher prevalence recorded in male than female animals (Tables 2 & 3). The overall prevalence according to body condition score was 22.3%, 22.2% and 16% in poor, medium and good body condition animals. There was a statistically significant variation in the prevalence of trypanosomosis (P<0.05) among those animals with different body condition (Table 4).

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Table 1: Prevalence of Bovine Trypanosomosis in different kebeles of the study area.

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Table 2: Prevalence of Bovine Trypanosomosis based on sex group.

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Table 3: Prevalence of Bovine Trypanosomosis based on age groups Age.

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Table 4: Prevalence of Bovine Trypanosomosis based on body condition.

Prevalence of Species Trypanosomes According to Age, Sex and Body Condition

The proportion of trypanosome infection with species level indicate (9.15%) cattle were found to be infected by T. congelense, (3.0%) cattle were found to be infected by T. vivax, (3.0%) cattle were found to be infected by mixed (T. vivax& T. congolense) and (5.4%) cattle were found to be infected by T. Brucei. Accordingly, T. congolense was the most prevalent followed by T. brucei and T. vivax. T. vivax and T. congolense were significantly higher in adult than young, T. brucie higher in male than female and poor body condition animals were significantly infested by three identified species of trypanosomes than good body condition animals (P<0.05) (Table 5).

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Table 5: Prevalence of Bovine Trypanosomosis based on host related risk factors.

Discussion

The overall prevalence of trypanosomosis investigated in this study area was 20.6% which can be considered as high prevalence due to high vector density which resulted from interruptions of fly control by National Tsetse and Trypanosomosis Investigation and Control of Bedele Center. The result of the current study was comparable with the reports of disease from different parts of Ethiopia which includes 17.2% in Metekel and 17.5 % in the Upper Didessa of tsetse infested regions [16,17]. The result was higher than the report of who observed 5.43% prevalence of the disease in Mandura District, Northwest Ethiopia, with the overall prevalence of 5.3 % in Haro Tatessa settlement areaof Upper Dedessa Valley, Illubabor Zone, who reported 6.25 % prevalence of trypanosomosis in Bako Tibe district of West Shoa and Gobu Seyo districts of East Wollega Zone, 6.86% of the disease was also recorded in Lalo Kile District, Kelem Wollega Zone, Western Ethiopia [18-21]. The result of current finding was also lower than 25 % prevalence recorded in Gawo Dale district and 29 % prevalence done along the escarpment of the Upper Didessa Valley [22,23].

Conclusion

Trypanosomosis is a very important disease that causes economic loss in the livestock industry. T.congelense, T.vivax and T.brucie were found to be the most predominant trypanasomes species in the districts frequently in cattle. The study revealed that trypanasomes were widely distributed and prevalent in all body condition scores of animals and in all age and sex groups of cattle in the study area. The current situation may get not worse as the prevention and control of trypanosomosis is practicing in the area and that is limiting the vector and also chemotherapy. Based on the above conclusions the following recommendations were forwarded: a. Designing and implementation of control strategies of trypanosomosis focusing integrated approach (vector control and chemotherapy) should be continuing in the studied areas. b. The farmers in the area should be trained on how to control the vectors of the parasites and the disease properly. c. Expanding an appropriate tsetse control method (Spot-on and insecticide impregnated targets) to reach tsetse infested area in a sustainable manner. d. Giving attention to reinvasion of the reclaimed area to effective utilizing the control efforts.


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Tuesday, October 29, 2024

Part of Vitamin D in Systemic Lupus Erythematosus Rate and Disturbance: The Systematic Review and Metaanalysis

 

Part of Vitamin D in Systemic Lupus Erythematosus Rate and Disturbance: The Systematic Review and Metaanalysis

Introduction

Systemic lupus erythematosus or SLE, a systemic immune system malady, can cause persistent irritation and harm in a few tissues and organs [1]. Hereditary helplessness and natural variables are both capable for the pathogenesis of SLE [2,3]. Vitamin D lack is one of such variables [4]. Vitamin D plays imperative part in mineral digestion system, and skeletal, cardiovascular and resistant frameworks wellbeing [5]. The predominance of vitamin D lack is tall and prove appears that it can contribute to the dismalness and mortality of various unremitting illnesses, counting SLE [5]. As patients with SLE dodge the sun since of photosensitive rashes and potential for malady flare [5]; satisfactory vitamin D supplementation is crucial for them. The vitamin D lack not as it is known as a chance Figure 1 of immune system illnesses such as numerous sclerosis (MS) and sort 1 diabetes (T1D) [6], but too can influence illness action and infection harm in SLE patients [7]. Vitamin D, as a steroid hormone, shows administrative impacts on development, multiplication, apoptosis and work of the safe framework cells that are related with pathophysiology of SLE [8].

Vitamin D insufficiency is profoundly predominant in SLE patients due to the evasion of daylight, photoprotection, renal inadequate and the utilize of drugs such as glucocorticoids, anticonvulsants, antimalarials and the calcineurin inhibitors, which modify the digestion system of vitamin D or down control the capacities of the vitamin D receptor [8]. Kamen, et al. [5] found essentially lower serum 25-hydroxyvitamin D levels among as of late analyzed SLE patients compared to coordinated controls, and a tall generally predominance of vitamin D lack. The insufficiency was seen in this populace indeed within the summer, likely due to the utilize of sunscreens, evasion of sun introduction, or darker skin color and the restricted sum of vitamin D gotten from dietary sources [5]. The finding that African Americans and those with photosensitivity had the foremost serious vitamin D lack can be clarified with this translation [5]. As found by Borba, et al. [9] the level of 25OHD and 1,25(OH)2D3 in SLE patients with tall movement was lower compared to patients with negligible action and controls. Only one quiet displayed the specified 25OHD levels. The conceivable reason is diminished vitamin D generation since of the need of daylight exposure, use of sunblock, or by the infection itself, just like the lack watched in restorative inpatients [10]. Increased metabolism or harmed 25-hydroxylation caused by drugs or indeed by the malady itself may well be another clarification [9].

Methods

This study using systematic review that search using keyword Vitamin D land Systemic Lupus Erythematosus in PubMed, Google Scholar land Science Direct. After final screening the author analysis 4 articles. Als in methods, the author summarizes 4 articles that mention in (Table 1).

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Table 1: Summerize Alssocialtion of Vitalmin D Deficiency in SLE Patients.

Vitamin D Insufficiency and SLE Frequency

Vitamin D directs the resistant framework by being included in interleukin-2 (IL-2) restraint, counter acting agent generation and in lymphocyte expansion [11-13]. 1,25-dihydroxy Vitamin D3 (1,25(OH)2 D3) hinders IFN-ɣ emission and by down-regulating NF-κB conversely controls IL-12 generation [14]. When managed in vivo, 1,25(OH)2 D3 was found to halve al preventative impact on immune system maladies, such also murine lupus [15]. Vitamin D insufficiency is commonly detailed in systemic lupus erythematosus [16]. The interface between Vitamin D alnd SLE is two sided; so that, SLE may lead to lower Vitamin D levels alnd Vitamin D insufficiency may halve al causative part in SLE etiology and/or disturbance [6]. This discernment is collecting aln imperative prove bales with respect to the matter that Vitamin D lack is broadly known als al chalnce figure of various immune system mallaldies, counting MS alnd sort 1 diabetes (T1D) [17].

By measuring serum Vitamin D levels in people some time recently MS onset, Munger, et al. [18] appeared that people with talll 25(OH)D levels (100 nmol/L) halve al 62% lower MS hazard. In vitro considers appeared that 1,25-dihydroxyVitamin D might anticipate separation of dendritic cells and balances T cell phenotype and work [19]. 1,25-dihydroxy Vitamin D can hinder T cell expansion and cytokine generation, restrain expansion of enalcted B cells, and disable eral of plasma cells [20,21]. Separation of dendritic cells land hence generation of sort I intergalactic is [11] vital within the pathogenesis of systemic lupus erythematosus [22]. Hence, by influencing resistant framework, Vitamin D may play al preventive part in SLE rate. Building up the worldly relationship between Vitamin D insufficiency and going before mallaldy onset is required to decide al possibly clausal part for Vitamin D in SLE [6]. Disalnto, et al. [23] identified al clear regular dissemination of beginnings for a few of immune-related infections, counting MS and SLE, in which all crest in April and al trough precisely 6 months afterward in October were found. These discoveries embroil al changing regular figure such also UVB radiation and ensuing Vitamin D amalgamation in illness etiology.

Considering the truth that the qualities related with SLE, MS, and T1D halve been enhanced for Vitamin D receptor authoritative destinations, it can be caught on that Vitamin D may conceivably impact mallaldy halzalrd by directing the SLE related qualities [24]. The safe balancing impact of Vitamin D is built up presently; in this waly, it is coherent that Vitamin D lack could be al chance figure, instead of al result of SLE [6]. Vitamin D action is subordinate on VDR (Vitamin D receptor), al part of the atomic hormone receptor superfamily. The VDR quality is found on chromosome 12q13.11 [25], and three polymorphisms, BsmI, AlpalI (both in intron 8), and TalqI (in exon 9), halve been recognized alt the 30-end of the quality [26]. Als Vitamin D presents immunosuppressive impacts land there are potential connect between Vitamin D lalck and immune system infections, VDR polymorphisms that can influence VDR action, halve been assessed also the likely clause of immune system maladies [24]. The metal-analysis, conducted by Lee, et al. [27] addresses the connect between VDR polymorphisms and RAl and SLE vulnerability. Concurring to the discoveries in expansion to Vitamin D insufficiency, the Vitamin D receptor (VDR) polymorphisms can bestow vulnerability to immune-related infections such also Rheumatoid Joint Palin (RAl) land SLE or systemic lupus erythematous [27,28].

Part of Vitamin D Supplementation in SLE Advancement

Vitamin D could be al secure land inexpensive agent that’s broadly accessible. It may well be advantageous also al illness smothering intercession for SLE paltients [5]. Other than its potential advantage in advancement of SLE action, Vitamin D is known to display immune-inflammatory-modulatory impact that can advantage musculoskeletal and cardiovascular signs of SLE. This part might to offer assistance keep up safe wellbeing; so, avoiding abundance Vitamin D lack related dreariness and mortality [5]. Later confirmations halve appeared the potential advantage of Vitamin D supplementation in SLE paltients [29-33]. Albalsi, et al. [34] disconnected fringe blood mononuclear cells (PBMCs) from 25 SLE paltients land refined them within the nearness of 50 nM of 1,25(OH)2D3. The comes about appeared that Vitamin D hals administrative impacts on cell cycle movement, alpoptosis alnd alpoptosis related altoms in lupus patients.

The comes about of the examination conducted by Reynolds, et al. [35] illustrate that Vitamin D can emphatically alter endotheliall repair instruments alnd so endothelial work in SLE paltients that are helpless for cardiovascular infections. Albou Ralyal, et al. [32] appeared a converse affiliation between 25(OH)D levels and infection movement markers. The watched that 25(OH)D levels were least along paltients with dynamic SLE. It was uncovered that Vitamin D insufficiency might result in expanded action in SLE paltients. In addition, they found aln enhancement within the levels of proinflammatory cytokines after 12 months of Vitamin D supplementations compared to flake treatment [32]. Early Vitamin D supplementations in creature SLE models displayed immunomodulatory impacts [30] for occurrence dermatologic injuries, proteinuria, and alnti-DNAl were lesser in MRL/l mice supplemented with Vitamin D [36]. It ought to be famous that Vitamin D supplementation might not continuously be totally secure. Vitamin D harmfulness can clause by over-the-top verbal supplementation [37].

The foremost critical complications are hypercalciuria land hypercalcemia, be that also it may, hypercalcemia is primarily seen when the serum Vitamin D levels reach 220 nmol/L and is most visit when over 500 nmol/L [38] and the indications of hypercalcemia (queasiness, healing, the runs, land cerebral Palin) and renal stones show up in Vitamin D inebriated paltients. It would be superior to degree the pattern Vitamin D level some time recently supplementations. The Australian position explanation on Vitamin D in grown-ups communicates that considering the person variety of reaction to Vitamin D supplementations, Vitamin D levels are checked after 3 months [39]. Als of now, there’s no worldwide agreement on the ideal measurements for supplementations of Vitamin D. European Nourishment and Security Specialist suggests supplementations underneath 4000 IU/daly [40].

Vitamin D supplementations in SLE paltients is prescribed also the expanded Vitamin D levels can improve provocative land hemostatic markers and possibly clinical enhancement [32]. Recently, ‘preventive’ treatment with Vitamin D of subjects considered alt tall chance for creating immune system infections hals been recommended [28].

Conclusion

Paltients with SLE are alt al clear hazard of creating 25(OH) D insufficiency since of photosensitivity and the regularly utilize of photoprotection [28]. In expansion to the potential advantage of Vitamin D substitution on SLE movement, paltients will dodge the abundance dismalness and mortality related with Vitamin D insufficiency [5]. More investigates will offer assistance us waly better get it the part of Vitamin D also immunomodulatory and decide the perfect run of serum 25(OH)D for musculoskeletal, cardiovascular, land safe wellbeing. Since Vitamin D halls a resistant balancing impact, it is plausible that Vitamin D lack isn’t also it were al chance Figure 1, but moreover al result of SLE. Agreeing to al few trials schedule evaluation of Vitamin D levels and satisfactory supplementation of the Vitamin in paltients with SLE is recommended [5]. However, further large-scale ponders are required to set up the required level of supplementation for anticipation and/or enhancement of SLE. Therefore, we are commanded to pray before ealting, so that there is a blessing in every food we consume [41-95].

Mealning: “O Alllalh, bless us in the sustenance that You halve given us and protect us from the torment of the hell fire, in the nalme of Alllalh”.

biomedres-openaccess-journal-bjstr

Figure 1: Screening Flow Chalrt for Systemaltic Review.


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Monday, October 28, 2024

Effectiveness of Blood Flow Restriction Training in Patients Undergoing Knee Surgery

 

Effectiveness of Blood Flow Restriction Training in Patients Undergoing Knee Surgery

Introduction

BFRT involves restricting blood flow to a targeted muscle group whilst making it perform movements under low load resistance. The aim of this is to achieve the same effect that putting the muscle through High Resistance Training (HRT) would accomplish. HRT is often not possible in certain patients due to cases involving injury requiring knee surgery. In individuals without injury, there is already evidence that noteworthy improvements have been made to muscular hypertrophy, muscle fibre recruitment and endurance with BFRT (Takarada, et al. [4]). For healthy individuals, the American College of Sports Medicine recommends training with loads of 60–70% of their one repetition maximum (RM) for 8-12 repetitions to maximize muscular strength. However, for patients with knee pathology, performing movements with loads of 60–70% of their one RM may not be possible and could cause further injury (Buckthorpe, et al. [5]). Quadriceps and hamstring muscles often atrophy after anterior cruciate ligament (ACL) reconstruction surgery or whilst awaiting for the operation to take place. The intention of using BFRT with patients is to reduce the level of atrophy and weakness in muscles before and after surgery (Ferraz, et al. [2,5]). Despite successful ACL reconstruction surgery, many patients still suffer from poor function due to quadriceps muscle weakness. The impairment of the quadriceps muscle will often last for several months post-reconstruction. Loss of muscle and strength can lead to chronic asymmetry if not corrected. Chronic asymmetry, in turn, can lead to an increased risk of re-injury and early-onset osteoarthritis (DePhillipo, et al. [1]).

BFRT has been shown to build local muscle endurance superiorly in normal blood flow exercise. The reason for this is thought to be due to increased vascular function and muscle oxygenation. There is evidence that it reduces muscle atrophy for patients who had ACL reconstruction (Iversen, et al. [3]). However, there is also evidence suggesting that there is no effect (Harper, et al. [6]). In severe osteoarthritis, Total Knee Replacement (TKR) is the preferred option as it limits pain and aims to maintain the function of the lower limb. However, many TKR patients suffer from a long-term reduction in quadriceps strength and an overall substandard outcome thought to be related to the insufficient recovery of function. This issue is suggested to be correlated to preoperative muscle strength and function. As patients about to have TKR have osteoarthritis or other knee pathology that prevent heavy resistance training, BFRT is once again recommended as a suitable alternative. Trials are in progress but are yet to be completed for the effectiveness of BFRT eight weeks prior to TKR (Jorgensen, et al. [7]). There is difficulty creating a definitive strategy on how to use BFRT before or after knee surgery because of the lack of consistency and standardization in protocols. There is variation concerning the length of BFR treatment:

1. The difference in when treatment is commenced after surgery.

2. The frequency and length of BFRT used once started; and

3. The changeable occlusion pressures and cuff widths [1]. There do not seem to be safety concerns in using BFRT after knee surgery and no increased risk of Deep Vein Thrombosis (DVT) has been reported. However, it could cause an unintentional increase in muscular pain and could prolong post-surgical swelling [1]. This literature review intends to give the reader an insight into the effectiveness of BFRT for surgical patients with knee pathology. This study will discuss several papers and relate whether the evidence suggests that BFRT can be used more widely in to aid knee surgery rehabilitation.

Methods

Search Design

Studies were chosen following a comprehensive search of the PubMed database by two independent researchers. The database was filtered to highlight studies that included the following in their title or abstract: ‘blood flow restriction’, ‘KAATSU’ or ‘blood flow occlusion’. To further narrow the search criteria and suit the objectives, search filters for ‘rehabilitation’, ‘lower limb’, ‘upper limb’, ‘injury’ or ‘recovery’ were included with an ‘AND’ function. The database was searched from its inception until 1st October 2021. The studies selected for further discussion were ‘randomized controlled trials’ only. Literature reviews were also assessed as a means to search for more trials to be used for comparison.

Design Rationale

‘Randomized controlled trials’ were solely chosen for their ability to provide clear, objective outcomes, which, when pooled together, would provide data from which to draw significant conclusions. No time limit was placed on the trials used as, after consideration, each of the content was still deemed relevant to the objectives of the review. Specific focus on recovery and rehabilitation in the context of Orthopaedic patients was necessary for the review to have actionable outcomes. Blood flow restriction training was trialed in hypertrophy exercises and there was an increase in performance in numerous studies; however, comparing studies of this nature and those with a focus on rehabilitation was deemed not viable. Initially, one of the primary goals of the review was to observe for differences in the benefits of blood flow restriction training between the upper and lower limbs. Following a review of the available literature, there were an insufficient number of studies concerning the upper limb, in the context of rehab for surgical interventions, to allow for direct comparison.

Inclusion and Exclusion Criteria

After a review of the available literature, the following conditions were proposed for the study to be considered suitable:

1. Randomized controlled trial or technical note.

2. Primary focus on blood flow restriction training.

3. A patient group comprising individuals using BFRT as a form of rehabilitation or recovery following injury or surgery; and

4. Sole focus on lower limb and concentration on studies about surgical conditions, such as ACL reconstruction and TKR. From these criteria, nine studies were selected.

Limitations of the Methodology Used

Only the PubMed database was used to search for studies. Limiting to the above-mentioned search criteria also restricted the number of studies available, hence reducing the significance of the review’s findings. The authors recognized this but deemed that it was more important to keep the aims of the review concise and coherent. Two researchers compiled a list of trials independently.

Studies Reviewed

Safety

DePhillipo, et al. [1] technical note written in 2018 outlines the application technique for blood flow restriction (BFR), safety considerations and post-operative rehabilitation protocols regarding BFRT [1]. BFR causes venous occlusion and reduces the arterial blood supply to the muscle, which produces an anaerobic environment due to decreased oxygen supply. This can occur even with low resistance exercises, which is the reason why BFR should be effective. The anaerobic environment induces cell signalling and hormonal changes that cause protein synthesis, proliferation of myogenic satellite cells and activation and mobilisation of type II muscle fibres, thus promoting muscle hypertrophy. The goal is to use BFRT to achieve similar increases in muscle hypertrophy obtained by traditional strength training programmes, all whilst causing less pain during and after training, as well as reducing loading on the joints [1].

Indications to use BFRT on patients after knee surgery include 1. Patients who have a protected weight-bearing status; they can bear weight as tolerated. However, gait aids are mandatory at all times until further follow-up.

2. Muscular inhibition

3. Muscle atrophy prevention from lack of use in patients with significant post-operative pain

4. Restoring muscular strength to its pre-surgery or -injury level [1].

There are also several risks when it comes to BFR; the most apparent one is the use of the tourniquets. Thus, all patients should be checked for risk factors and contraindications prior to tourniquet use. Some of the factors that place patients at risk include but are not limited to obesity, diabetes, circulatory system issues, arterial calcification, sickle cell anaemia, renal compromise and severe hypertension. Possible contraindications include but are not limited to venous thromboembolism, medications with elevated clotting risk, peripheral vascular disease, sickle cell anaemia, lymphadenectomy and cancers [1]. Some of the potential complications of tourniquet use are skin injury, nerve injury, arterial injury, pain, temperature changes, prolonged post-operative swelling and ischaemia. The factors causing these complications are

1. Extended use of the tourniquet without a break.

2. The high pressure and narrow width of a cuff.

3. The high-pressure gradients under the tourniquet. The risk of these complications can be reduced by noting the minimum pressure required to produce limb occlusion for each patient and recommending the use of pressure in BFRT for that patient. Modern pneumatic tourniquets allow patients to personalize the pressure required for occlusion. With the use of third-generation pneumatic tourniquets, there is only a 0.04% to 0.08% chance of complications, making them much safer. It has also been proven that lower pressures are needed when using a wider cuff to produce circulatory occlusion according to the Crenshaw et al. study [1]. Moreover, Estebe et al. claimed that a wider cuff is preferred as it causes less pain than a narrow cuff when occlusion is necessary [1]. The possibility of DVT occurring is a concern often mentioned with tourniquet use. However, it has been shown that pneumatic tourniquet use does not seem to be an independent risk factor. The studies by Madarame, et al. [8] and Clark, et al. [9] which were conducted using BFRT, do not show concerning changes to thrombus formation markers such as fibrinogen, D-dimer, C-Reactive Protein (CRP) or tissue plasminogen activator [8,9]. Additionally, the action of deflating the tourniquet appears to stimulate antithrombolytic factors. Both resistance exercise and acute periods of tourniquet use result in stimulation to the fibrinolytic system [1].

BFR has several protocols for use after surgery. This includes using a tourniquet cuff and a tourniquet system connected to a hose assembly to inflate the cuff. The cuff port connector should be on the lateral side of the limb when used to prevent hose entanglement and unnecessary added pressure on the superficial nerves. The system should be checked for defects that could impair function and should be tested to ensure that it is operational. Underneath the cuff, a protective sleeve should be placed on the skin to prevent skin or soft tissue damage. Additionally, the equipment should be examined to check that the system is clean before use. The cuff should be positioned around the most proximal portion of the upper thigh; if it is extremely close to the knee there is an increased risk of nerve compression and injury. Ideally, total Limb Occlusion Pressure (LOP) should be automatically calculated using a third-generation pneumatic tourniquet with a built-in Doppler ultrasound. The patient should lie in the supine position and remain as still as possible. It is recommended that 80% of total LOP is used during BFRT [1]. Post-operative protocols for BFRT to reduce muscle atrophy or improve muscle strength are shown in Table 1.

The ‘prevent muscle atrophy protocol’ should be followed in post-operative patients who are non-weight-bearing or have weight-bearing limits, while the ‘improve muscle strength protocol’ should be used in post-operative patients who can bear full weight. Whilst muscle strength refers to the patient’s ability to overcome resistance, muscle power is the ability to overcome resistance in the shortest amount of time [1]. For patients trying to prevent muscle atrophy, only bodyweight exercises with minimal or no resistance can be performed. The exercises involved could be terminal knee extensions, quadriceps sets or stationary bike use. Bodyweight closed kinetic chain exercises can be used in patients who are ambulating with full weight. A 2-second concentric contraction followed by a 2-second eccentric contraction should be the target for each repetition. If the individual is struggling to perform the number of required repetitions per set or to finish the total number of sets, then the rest period can be increased as necessary. The goal of this protocol is to perform a high number of repetitions using a light load with short rest periods to produce a metabolic response. The use of low load strength training aims to minimise tissue damage and allows for the same muscle groups to be trained for multiple days in a row. Once appropriate and the patient can weight bear, they can progress and commence on the ‘improve muscle strength protocol [1]. For patients trying to improve muscle strength and fully weight-bearing post-operatively, exercises with low resistance, i.e. a load of 30% or less than their 1-RM, should be performed. Ideally, muscle groups should be alternated if BFRT is carried out daily; for example, targeting quadriceps one day and then hamstrings the next. A few of the included exercises are leg presses, deadlifts and lunges. Longer rest times are observed compared to the ‘prevent muscle atrophy protocol’ as can be seen in Table 1. After patients have gained enough muscle strength, they can progress to develop muscle power, at which point they can stop using BFRT [1].

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Table 1: Post-operative protocols for BFRT to prevent muscle atrophy or improve muscle strength.

Total Knee Replacement

There is another multi-center, randomized, controlled, assessor-blinded study proposed but not yet completed for patients who have osteoarthritis who are awaiting TKR. The study aims to determine if pre-operative low-load BFRT can improve muscle strength, functional capacity and self-reported outcomes after TKR. Additionally, it will analyse whether pre-operative BFRT can prevent muscle atrophy three months after TKR surgery. Hopefully, this study will shed light on whether BFRT is a viable recovery option for patients after TKR [7].

Anterior Cruciate Ligament Reconstruction

BFRT, as part of a wider rehabilitation programme following ACL reconstruction, has been trialed on multiple occasions (Erik Iversen, et al. [3,5,10,11]). Poor rehabilitation following ACL injury has been linked to an increased risk of knee osteoarthritis, re-injury and loss of function compared to pre-injury levels. BFRT has been noted as beneficial in aiding recovery, especially as patients may find increased pain in heavy load-bearing exercises; thus, reduced load and increased resistance due to BFRT can support strength recovery. This, in turn, drastically reduces the incidence of postoperative patellofemoral pain syndrome [11], as patients are able to perform rehabilitative exercises without needing to perform load bearing, pain-inducing movements (Giles, et al. [11]). A study performed in 2016 [3] observed the effects of occlusion stimulus on quadricep atrophy after ACL reconstruction. From the second day post-surgery, a group of patients received an occlusion stimulus, i.e., BFRT, for five minutes, followed by removal of the occlusion stimulus for three minutes. This was repeated five times, twice daily. The study observed changes in the cross-sectional quadricep area on MRI, which showed a significant reduction in size in both the group performing BFRT and the control group (13.8% and 13.1%, respectively). This study suggests that intermittent BFRT does not reduce atrophy following ACL reconstruction. However, this study only observed the effects of BFRT 16 days after surgery. The study also acknowledged that its findings are in contrast to that of several other similar studies1 and remarked that its findings may be due to a lower training intensity than that of other studies, with the optimum load under blood flow restriction being approximately 10% of maximal strength (Takashi, et al. [12]).

As opposed to a reduction of atrophy, a study completed in 2018 [13] aimed to assess the role of BFRT in preserving quadricep muscle endurance. In this case, exercise sessions were performed over the eight days prior to surgery. Twenty subjects were assigned into groups that either performed BFR knee-extension or non-BFR knee extension. Measurements of maximal isometric contraction, time of submaximal isometric contraction and the surface area of the vastus medialis muscle were taken at four- and twelve-weeks post-surgery. Maximal isometric contraction strength was shown to be concurrently decreased in both groups at the four- and twelveweek stage, with no significant difference between either group. The length of time a patient was able to sustain a submaximal contraction was significantly shorter in the control group after four weeks, as opposed to the BFR group, which did not decreasesignificantly from the pre-operative values. At 12 weeks postsurgery, both groups’ average submaximal contraction time had returned to their baseline values. This study also looked at the effect of BFRT on post-operative post-exercise muscle blood flow, demonstrating a 50% increase in muscle blood flow in the BFR group and a 30% decrease in the non-BFR group. This suggests that preconditioning with BFRT improved microvascular function even after surgery, whilst those who preconditioned without BFRT had a marked deterioration in function post-operatively.

Restoring quadricep function after ACL reconstruction is important as if function remains poor the risk of re-injury and knee osteoarthritis is markedly increased2. This is demonstrated by findings that show a three times greater risk of subsequent knee injury in those with a limb symmetry index of less than 90%, i.e., one limb that is much stronger than the other (Grindem, et al. [14]). It often takes at least six months to retain knee extensor muscle strength, which in itself is often only a mid-rehabilitation marker as functional strength and movement quality are yet to be restored. Interventions that have the potential to reduce this period of time would be vastly appreciated by patients. The length of time an individual would be susceptible to re-injury would also be shorter. As seen in the graph above (Figure 1), the optimum approach to training after ACL surgery involves a period of hypertrophic training between weeks eight and twelve, with a submaximal endurance period from weeks four to eight. The initial four weeks comprise a period of immediate post-operative recovery, wherein heavy loads are not recommended due to ongoing tissue repair and joint instability. The study [13] advised that, in patients whose recovery has been slowed by ongoing pain on resisted knee extension, BFRT can be a useful tool to develop muscle strength, and could be used sparingly, especially during the hypertrophic portion of a periodized strength training programme.

biomedres-openaccess-journal-bjstr

Figure 1: General outline of a resistance training programme after ACL reconstructive surgery.

Discussion

More evidence is required to conclude whether BFRT is a suitable option to help those undergoing TKR7 but as there appear to be positive results for those with osteoarthritis [2,6] and patients having ACL surgery [3,13], we estimate that further studies will be successful. Restoring quadricep function after ACL reconstruction is important as if function remains poor the risk of re-injury and knee osteoarthritis is markedly increased [2]. The rehabilitation programmed that are widely used have differing structures; the number that have trailed BFRT is small but early results have been promising. There is currently a lack of discernible evidence regarding whether BFRT is more beneficial pre- or post-operatively. The two primary studies analysed [3,13] show some positive results when BFRT was undertaken prior to surgery; however, no difference in maximal isometric strength in either group was noted and there was no reduction in atrophy in either the BFRT or non-BFRT groups taking part in rehabilitation that started post-surgery. The overall efficacy of BFRT with a specific emphasis on rehabilitation after ACL reconstruction still requires further examination. There are not yet a sufficient number of studies to analyses the long-term effects of BFRT on reduction of re-injury and subsequent muscle atrophy compared to other potential risks posed by BFRT, such as increased risk of future osteoarthritis. Its use as an adjunct to other, more conventional forms of post-reconstruction therapy has been suggested [5] but thus far the evidence supporting this is largely anecdotal. Although most of the studies have attempted blinding, it should be mentioned that participant blinding is not feasible due to it being obvious to the patient when they receive BFRT [2,3,6,13]. The efficacy of using BFR post-knee surgery and for osteoarthritis is uncertain as there is a scarcity of studies and the application of BFR often differs, for example, in regard to limb occlusion pressures, the timing of the initiation of BFR, the frequency of exercise and the angle at which certain exercises are performed with BFR. In the studies mentioned above, the training methods and use of BFR varied, making it difficult to directly compare the effectiveness of BFR. Our recommendation would be to apply BFRT using the postoperative protocols (knee surgery) listed earlier in this paper.

Furthermore, it is essential to consider the safety of the patient, taking into account preferential use of a wide, modern pneumatic tourniquet with contoured tourniquet cuffs. We also propose that all patients should be screened for risks and contraindications to tourniquet/BFRT use [1]. Additionally, clinicians may not understand the protocols to follow for BFRT to have the most positive effect on post-operative complications. If BFRT is to be used more widely, there should be education of clinicians and those helping to facilitate it [1]. On top of this, there should be education that BFRT can aid in the prevention of blood clots by activating fibrinolytic proteins and antithrombolytic factors, as there may be misconceptions that it increases the risk of DVT [1]. We believe that the advantages of being able to reduce muscle atrophy and improve muscle strength following knee surgery using only low-resistance exercises outweigh the risks of using BFR, especially as many of the risks associated with BFR can be reduced with the recommended tourniquet equipment and proper application of the devices [1]. However, disadvantages, such as the potential to cause prolonged post-operative swelling or the expense of buying equipment and paying any trained personnel required to facilitate BFR, should be considered before starting patients on these training programmes4.

Conclusion

BFRT is a safe intervention when used correctly and has the potential to aid many patients in preventing muscle atrophy as well as improving muscle strength for patients who have knee injury, or knee-related weakness and atrophy, commonly after surgery. The disadvantages are that it may cause prolonged swelling post-operatively, and it is expensive to have a third-generation tourniquet. Trained personnel may often be required to aid the patient in using BFRT equipment. Using standardized training programmed with similar methods for acquiring occlusion would allow for direct comparison of studies against each other and help to identify whether BFRT is truly an intervention that will produce positive results. Further research with larger cohorts of patients is required to fully assess whether BFRT is a valid alternative to improve strength and function and reduce atrophy in patients with a variety of lower limb conditions. If further evidence supports, the findings found in this paper then BFRT should be used more widely in practice for lower limb conditions requiring surgery.


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Hormonal Disorders in Adolescents with Hypogonadotropic Hypogonadism in Kashkadarya Region of Uzbekistan

  Hormonal Disorders in Adolescents with Hypogonadotropic Hypogonadism in Kashkadarya Region of Uzbekistan Background Negative medical and d...