Abstract
#Metabolomics [1]. As a formidable tool, is usually used to
systematically assess the molecular responses of living systems
to all external stimuli, characterize #pathologicalstates, diagnostic
information and mechanistic insights into biochemical effects of
drugs, based on global metabolite profiles in biological samples [2].
#Massspectrometry (MS) and nuclear magnetic resonance (NMR)
spectroscopy, two major analytical platforms, with visualization
software, have driven forward the discipline of metabolomics.
Traditional Chinese #Medicine (TCM) with its focus on herbal use is
popular and appreciated worldwide with increased tendency [3,4].
And treatment was perceived as fairly safe but discussions emerged
more recently as to whether herb-induced liver injury (HILI) from
#herbal TCM is a major issue. The multi-component and multi-target
nature of TCM makes toxicological research far more complex
than that of chemical drugs. Looking for rapid and sensitive
biological toxicity effect evaluation technology has become a major
problem urgently to be solved in current TCM safety evaluation.
Metabolomics can further be employed as a perfect approach to
link the gap between TCM and molecular #toxicology. We reviewed
the applications of the metabolomics with two major analytical
platforms for HILI researches.
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Metabolomics Used in Herb-Induced Liver Injury by Geng Xingchao in BJSTR
