Abstract
In 2002, a pioneering work on single cell coating with
macromolecules through layer-by-layer (LbL) method was
published in Langmuir [1]. Yeast cells were alternately coated with
#cationic and anionic #macromolecules. Even after coating, the cells
still survived. Inspired by the work, multilayered macromolecules
have been used for coating various types of microbial cells and
#endospores [2]. Although the survival of #microbialcells in the
artificial coat was interesting of itself, the impact of works was
under evaluated in the biomedical fields because the method was
limited to microbial cells and the macromolecular coating had no
particular roles. The two limitations have been gradually solved by
developing functional coating materials and applying the method
to mammalian cells. The function of coating materials was mainly
improved by shifting from organic macromolecules to inorganic
materials, in other words, from soft to hard materials Tang et al.
[3-6]. crystalized calcium phosphate on the #multilayer-coatedyeastcells, leading to rigid artificial shells [7]. Choi et al. synthesized
silica on the multilayer-coated yeast cells in a #biomimeticmanner,
which was the first report on coating living cells with covalent
bonded inorganic materials [8-10]. And chrollera cells were coated
with Titania using #catalyticpeptides [11].
For more Biomedical open access journals please click on https://biomedres.us/
For more Research Articles on BJSTR
#Coating of Single Cells towards Biomedical Applications by Sung Ho Yang in BJSTR
