Tuesday, December 11, 2018

The Zemblanity of Missing Subtile Changes in the Patient'S Blood Tests-Diagnosing Hereditary #Spherocytosis After Finding Extramedullary #Haematopoiesis by Ana Margarida Dantas Brito Rodrigues in BJSTR

Abstract

We report a #clinicalcase of #hereditary #spherocytosis in the view of it´s educational value. The diagnose was overlooked for many years while the patient was a regular blood donor. This was probably the stress factor that precipitated the development of extramedullary #haematopoiesis in a patient that otherwise had a rather mild phenotype. The authors want to stress the importance of valuing the red cell indexes as an informative part of the #hemogram. A 59-year old female patient was referred to the lymphoma department. The patient's previous medical history was unremarkable. Symptoms started after she had an accidental fall on her back, and she was in need of analgesics for some time because of back #pain. Eventually she consulted her family physician who ordered a thorax CT scan suspecting a #spinefracture

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The Zemblanity of Missing Subtile Changes in the Patient'S Blood Tests-Diagnosing Hereditary #Spherocytosis After Finding Extramedullary #Haematopoiesis by Ana Margarida Dantas Brito Rodrigues in BJSTR

Topological Space of the #Knee Tensegrity System by Wangdo Kim in BJSTR

Abstract

Estimating the #kneeaxis is crucial to both correctly aligning components in #kneearthroplasty and assessing the joint #kinematics. From the point of view of perceptual #psychology, it is especially interesting that one can use the part-whole relationship at the knee joint as the basic theory. We characterize the concept of a “knee axis” and further the concept of “surrounding.” It is now generally recognized that the whole-part relationship, and the relationships of the parts to each other play a fundamental role in producing the screw axis of the #knee (SAK). We present conditions of component alignment in the arthroplasty based on the principle that the part should become a member of the whole. If any screw motion with respect to the SAK is applied to the lines of forces that form the surrounding, these forces remain within the surroundung.

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#Diagnosis and Management of Adverse Food #Reactions by W Jean Dodds in BJSTR

Abstract

#Adversefoodreactions in people and pets closely mimic those from environmental #allergen and contact exposures, and are manifested typically as cutaneous or gastrointestinal signs or both [1-6]. #Neurologicalsings including #memoryloss, confusion and cognitive #dysfunction may also occur, especially in the aged. Some experts equate the increase in food-related disorders in pets with the promotion of dry kibble and wet canned foods by the commercial pet food industry, to address the time-strapped societal demands of our fast-paced Western world [6]. The question arises, however, whether modern domestic dogs and cats can adequately digest and assimilate dry commercial pet foods, when they are ancestrally #carnivorous. Although cats have maintained their carnivorous nature over decades, dogs have evolved with domestication by adapting #genomically a starch-rich diet [7]. This evolutionary adaptation of canines from the carnivorous wolf targeted 19 of the 36 genomic regions which contained genes important in brain function and behavior, and ten genes with key roles in starch digestion and fat #metabolism [7].

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Understanding the Detection of Shiga Toxin Producing #EscherichiaColi: Virulence Factors, Pathogenicity Islands or #Serotypes? by Colello, Rocio in BJSTR

Abstract

Shiga toxin-producing #Escherichiacoli (STEC) are important food borne #pathogens that can cause severe disease in children by producing two toxins (Stx1 and Stx2). This bacteria harbor several additional #virulence factorsand have been classified in different #serotypes that have been used as screening for detection of STEC. Aa is not possible to define when a STEC strain is pathogenic, it is important incorporate the risk assessment. Shiga toxin-producing Escherichia coli (STEC) are important food borne pathogens that can cause severe disease in children, including a life-threatening complication such as bloody diarrhea and hemolytic uremic #syndrome (HUS) [1]. The damage is produced by Shigatoxins encoded by stx1 and stx2 genes carried by #lysogenicphages that infect the bacteria [2]. STEC must intimately adhere to epithelial cells through #adhesions for deliver toxins efficiently to host organism.

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#GastricCancer Challenges in Young Adults: #Genetic and Socioeconomic Features in Different Brazilian Country Regions by Maria Aparecida Azevedo Koike Folgueira in BJSTR


Abstract

#Gastriccancer in young adults is a challenging situation. In Brazil, recent data indicates that most of them are diagnosed with advanced disease and that CDH1 #germlinemutations are not frequently detected. It is high time to characterize the spectrum and frequency of germline mutations in gastric cancer young patients and to improve health care to high risk individuals. More than 70% of gastric #cancer cases occur in developing countries, with the highest incidence rates observed in East Asia, Latin America, Central and Eastern Europe [1]. Although the incidence of stomach cancer has declined over the years 1975 to 2005 in several European countries, as well as in some Asian countries [2], in Brazil, the estimated age-standardized rate of new cases per 100,000 persons per year is still considered moderate/ high (9.2) as compared with the USA (3.9), France (4.7), Argentina (6.7), Spain (6.7), Italy (8.2), China (22.7) and Japan (29.9) [3]. In Brazil, there are estimates that 13,540 new cases in men and 7,750 in women, will occur in the years 2018-2019, indicating that gastric cancer assumes the fourth and the sixth places in cancer incidence among men and women, respectively [4]. 

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Monday, December 10, 2018

PD-1/PD-L1 Checkpoint in Breast Implant-Associated #Anaplastic Large Cell #Lymphoma: A Case Report by Antonella Bianchi in BJSTR

Abstract

#Breastimplant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare form of #malignancy that arises around mammary implants in patients undergoing #prostheticsurgery. It has been included as a provisional entity in the revised WHO classification of #lymphoidmalignancy. The PD-1/PD-L1 axis is one of the major mechanisms of #immune escaping exerted by several cancer types in which up-regulation of PD-L1 is observed. We report the presence of PD-1/PD-L1 checkpoint in a case of BI-ALCL of a 67 year old woman, whom previously had undergone mastectomy and reconstruction for breast #carcinoma.

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Performance Investigation of Batch Mode #MicrobialFuelCells Fed With High Concentration of #Glucose by Yongming Sun in BJSTR

Abstract

Two-chambered #microbialfuelcell (MFC) with Nafion117 as proton exchange #membrane (PEM) in the middle of reactors was built to treat the synthetic wastewater containing high concentration of #glucose in this work. This MFC can produce 95% removal efficiencies of the maximum chemical oxygen demand (COD) and the highest coulombic efficiency (Ec) of 24.4% at the glucose concentration of 1 g/L. It was found that when the feed of glucose concentration is changed from 0.5 g/L to 4.0 g/L the volumetric power density is decreased from 5.3 W/ m3 to 2.25 W/m3. When the glucose concentration is further increased to 12 g/L, almost no power output was observed. The optimized running concentration of glucose for as-designed MFC is between 0.5-4 g/L at the experimental conditions in this work. This work would pave a way for the direct treatment of #wastewater containing high concentration of complex #organiccontaminants.

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Presence of #OrganicPesticides in Commercial Rainbow Trout #Farms by Kleber Campos Miranda-Filho in BJSTR

Abstract

The objective of the present study was to evaluate the presence of #pesticides in different matrices, such as: water, fish, #soil and feed, during #rainbowtrout production in a raceway system. During the rainy and dry periods (2014 and 2015), the parameters temperature, pH, dissolved oxygen (OD) and alkalinity were also evaluated. The water matrix residues were extracted by the Luke method and fish, soil and feed matrices were extracted by the modified QuEChERS method. The extracts were evaluated by multi-residue HPLC-MS / MS analysis with limit of detection - LOD (1 ppb) and limit of quantification - LOQ (10 ppb). For the water matrix, residues of organophosphates, carbamates, #pyrethroids, #anilinopyrimidines, #strobirulins and #alkylsulfite were detected in the trout cultures. However, only organ #phosphorusinsecticides (chlorpyrifos and dichlorvos) were quantified. In trout farm A was detected and quantified chlorpyrifos at 0.019 mg/L point A1 and dichlorvos at the concentrations of 0.136 mg/L point A1 (tributary) and 0.0465 mg/L point A6 (effluent).

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Treatment of #OralPiercing Complications in Periodontal Tissues with the use of #Enamel Matrix by Leonidas Batas in BJSTR

Abstract

In the last decade, #bodypiercing has become increasingly fashionable especially among young adults. The growing trend of oral piercing must be a concern to dental professionals because of the risks and #complications in the #oralcavity. Oral piercings, such as #tongue and lip piercing, can cause several complications such as hemorrhage, pain, swelling, lingual nerve damage, gingival recession, infection, periodontal distraction and fractured teeth. The purpose of this paper is to present case reports and methods of treating the complications of tongue and lip piercing that appeared to the #periodontaltissues on the #lingual and #buccalsites of the #lowerincisors. In all cases EMD (Emdogain®) was used and the oral piercing was removed. All cases showed reduction of the pocket depth, gain in clinical attachment level and significant reduction of #gingivalrecession. As a conclusion the use of EMD may be a treatment of choice in patients that had periodontal damage after oral piercing and these results seems to be reproducible.

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A Rare Case of a #Non-Hodgkin'sLymphoma Presented As a Single #BoneLesion by Gregory Tsoucalas in BJSTR

Abstract

Primary #bonelymphoma depicts a 1-2% of adult #non-Hodgkinlymphomas. We report a rare case of a single bone lesion in a 28 years old female patient with her left femur afflicted. Our case aims to alert physicians upon a simple gait disturbance and mild #kneepain. #Hematologicalmalignancies present a clinical spectrum of #symptomatology which ranges from no focal skeleton lesions in #leukaemia to numerous lytic lesions in multiple #myeloma. Reports of a primary bone lymphoma (PBL) are rather rare, accounting for less than 1-2% of adult non-Hodgkin lymphomas (NHL) [1], commonly affecting mainly #femur, as well as spine and pelvis, causing dominantly localized bone pain [2]. We report a 28 years old female patient with NHL, presented as a single primary bone lesion on her left femur.

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Sunday, December 9, 2018

In Vitro #Analysis of the #Fracture Resistance of Cad-Cam Cerasmart Molar Crowns with Different Occlusal Thickness by Roberto Sorrentino in BJSTR

Abstract

Purpose: To compare the #fracture resistance and mode of failure of CAD-CAM #monolithic hybrid composite-nanoceramic crowns with different occlusal thickness.
Materials and Methods: Thirty CAD-CAM monolithic hybrid #composite-nanoceramiccrowns with different occlusal thickness were randomly distributed into 3 groups: 0.5 mm, 1.0 mm and 1.5 mm. The restorations were cemented onto human molars with a self-adhesive resin cement. The specimens were loaded until fracture; the fracture resistance and mode of failure were recorded.
Results: The strength of the specimens progressively increased with occlusal thickness; the highest resistance to fracture was reported in 1.5 mm-thick crowns but no statistically significant differences were noticed among the experimental groups (p>0.05). The ultrathin crowns (0.5 mm) were mainly interested by unrestorable fractures.
Conclusion: The #occlusalthickness of CAD-CAM monolithic crowns did not influence the fracture resistance of restorations but it significantly affected their mode of failure; the occlusal thickness of such restorations can be reduced up to a lower bound of 1.0 mm in order to keep sufficient strength to with stand occlusal loads; CAD-CAM monolithic hybrid composite-nanoceramic crowns showed sufficient fracture resistance to be used in molar regions but not in an ultrathin configuration (0.5 mm).

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Modulatory Effects of Human Bone Marrow-Derived #MesenchymalStemCells on Proliferation and Ultrastructural Changes in K562 #LeukemiCells by Ammu Kutty Radhakrishnan in BJSTR

Abstract

#Mesenchymalstemcells (MSCs) have been reported to possess modulatory effects on various types of cancers as well as #immunomodulatoryproperties, which have intrigued many researchers. Over the past two decades, there has been a focus in literature on the interaction between MSCs and #leukemias. However, the interactions between the MSCs and leukemic cells, in particular the k562 cells, have not been well documented. The aim of this study was to demonstrate the interactions between human #bonemarrow-derived MSCs (hBM-MSCs) on a chronic myeloid leukemic cell line (K562 cells). Co-culture of K562 cells with the hBM-MSC increased the viability of these cells in noncontact and contact co-culture conditions. The same was observed when the K562 cells were cultured in hBM-MSC conditioned medium. Transmission #electronmicroscopy (TEM) of K562 cells co-cultured with hBM-MSCs showed significant ultra-structural observations consistent with biochemical assays performed. The findings suggest that although cell-to-cell interaction is required for effective modulatory effect to occur, soluble substance secreted by the hBM-MSCs may also be able to emulate similar effects.

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Importance of the Tpk Gene Phylogenetic Relationships of the #ThiamineBiosynthesis Pathway for the Study of Plant Evolution #Phylogeny of the TPK gene in plants by Pereira AA in BJSTR

Abstract

Through the analysis of molecular biology, the relations between #organisms and the evolutionary order of the #species were inferred, not only through visual characteristics but also through genomic characteristics. #Vitamin B1 (Thiamine) is a vital #micronutrient required by all organisms. In view of the importance of this coenzyme, this work analyzed the TPK gene of the #thiaminebiosynthesis pathway in the evolution of terrestrial plants, using phylogenetic analysis tools. Thus, by evaluating the variations in protein level of the TPK #gene, it was possible to reflect the evolution of the large groups of plants, and even the proximity between species, families and orders.

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Early Cases of #DuodenalCarcinoma Invading the Portal Tract In The 1870s by Wilson IB Onuigbo in BJSTR


Abstract

Willis, in his famous book, wrote that Vogel was the first in 1891 to describe cancerous invasion of the portal tract. Therefore, this paper sets out to provide the earlier dates of the 1870s. Willis, in his far famed "The Spread of #Tumours in the #HumanBody," in 1973, mentioned that Vogel was the first to describe #cancerous spread to the #portaltract [1]. Therefore, since it is necessary to identify historical errors [2], any previous account should be documented.

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Antidiabetic and Antioxidant #Bioactivity of Various Potential #EndophyticMicroorganisms in Indonesia: A Mini Review by Toga Pangihotan Napitupulu in BJSTR

Abstract

#Entophytes are reliable source of #bioactivecompounds and #secondarymetabolites to various #naturaldrugs. This potential of entophytes is promising but not yet fully explored. This paper provides selected data for current research of entophytes with potency as ant #diabetic and #antioxidant in Indonesia.

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Friday, December 7, 2018

#Peritoneal #Cancer-an Atypical Clinical Case by Tihomir P Totev in BJSTR

Abstract

We present a 51-year-old female admitted for treatment of #ovariancancer with a #diagnosis based on inguinal #lymphnode biopsy. After PET/CT, followed by #surgery, the final diagnosis was peritoneal cancer. The primary site was not found and the only clinical sign was that of bilateral #inguinallymph node enlargement.

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Finite Element Stimulation Analysis on #OsteogenicCapacity of the Gelatin-Hybridized #CalciumPhosphate Cement by Noritaka Isogai in BJSTR

Abstract

When a bone defect is caused due to #craniotomy, skull reconstruction is performed with titanium plates or #hydroxyapatite in order to protect the brain and achieve an esthetically favorable outcome [1].These non-biodegradable #osteo-inducingmaterials remain in the body and are never incorporated into the auto logos bone. Skull reconstruction using these materials often evokes postoperative complication such as protrusion, #osteomyelitis, and instability. The use of biodegradable osteo-inducing #biomaterial that can be spontaneously changed to the antilogous bone would be ideal for skull reconstruction; however, such biomaterial has not been developed yet. We previously developed an inject able, biodegradable osteo-inducing biomaterial (gelatin-hybridized calcium phosphate cement, gelatin-hybridized CPC, Gunze Ltd., Kyoto, Japan), and demonstrated its estrogenic capacity using a rat model with a full-thickness skull defect. In the present study, we performed a histological analysis to investigate the influences of the degree of cross-linking and volume of gelatin contained within gelatin - hybridized CPC on the osteogenic capacity. Furthermore, we performed finite element simulation #analysis to examine the bone strength of the regenerated bone.

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Inhibitory Effect on Lipid Accumulation: Comparison between Two Polymethoxylflavones, Tangeretin and Nobiletin, and One #Flavonoid, Hesperetin, in 3T3-L1 #Adipocytes by Pin Der Duh in BJSTR

Abstract

In this study, two #polymethoxylflavones (PMFs), including #nobiletin and #tangeretin, and one flavonoid, #hesperetin with one methoxyl group, were investigated to inhibit lipid accumulation using 3T3-L1 adipocytes. The reducing lipid droplets of the three compounds at 50 μM followed the order nobiletin=tangeretin>hesperetin; the inhibition of triglyceride levels was in the order nobiletin> tangeretin> hesperetin, indicating the numbers of methoxyl groups on the benzene ring play an important role in reducing #lipidaccumulation. These results imply polymethoxylflavones with high degree of methoxylation are easily permeable to cell membranes and demonstrate more regulating #adipogenesis. The findings of this study are useful for designing new v and is therefore a potentially lipid lowering compounds based on chemical structure.

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Percutaneous #Verterboplasty as Treatment of Symptomatic Vertebral #Hemangioma by Shaharuddin Abdul Rhani, in BJSTR

Abstract

#Vertebralhemangioma is a benign #vascularlesion composing of new and malformed #bloodvessels, which occurs in the #spine. These tumors are usually asymptomatic and are incidentally diagnosed during #magneticresonance imaging, performed for other purposes. However, patients may present with pain if there is neural arch expansion, vertebral body enlargement or direct compression to the spinal cord or nerve roots. A number of treatments such as radiotherapy and surgery are used in the treatment of symptomatic patients but both methods have been burdened by complications. Percutaneous verterbroplasty, a minimally invasive procedure, has emerged as a treatment of symptomatic vertebral hemangioma with satisfactory results and low complication rates. We present here a case of symptomatic vertebral #hemangioma, which was treated with #percutaneousvertebroplasty.

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Management of #StomaProlapse: A Novel Technique for #Repair by Roger Christopher Gill in BJSTR

Abstract

We present to you a case of #stomaprolapse in a patient for whom reversal was not an option. Linear #GastrointestinalStapler was used to perform resection of the prolapsed segment and a perfect height stoma reconstructed. We present visual photographs of the steps of the procedure to facilitate learning for our surgical colleagues. Our patient did not require any pain killers or #antibiotics and was discharged the next day. Such simple and novel resection techniques for #surgical management of prolapsed stoma can easily be learnt by residents and consultants and can provide an important armamentarium in managing this #distressing complication.

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The Zemblanity of Missing Subtile Changes in the Patient'S Blood Tests-Diagnosing Hereditary #Spherocytosis After Finding Extramedullary #Haematopoiesis by Ana Margarida Dantas Brito Rodrigues in BJSTR

Abstract We report a #clinicalcase of #hereditary #spherocytosis in the view of it´s educational value. The diagnose was overl...