Monday, March 18, 2019

Biomedical Research Articles

Abstract

#Preeclampsia (PE) is a pregnancy-specific syndrome characterized by maternal #cardiac output (CO) alterations and relative #hypovolemia. In patients with PE is mandatory to predict Fluid Responsiveness (FR), above all if caesarean section (CS) under spinal anesthesia is required. The fluid challenge (FC) is a diagnostic approach to #hemodynamicmanagement which aims at identifying the patients who respond to fluid administration with an increase in CO. We present a case series to evaluate the effectiveness of a FC in increasing Cardiac Index (CI) in a group of #preeclampticpatients using a continuous pulse-contour analysis. We studied the percentage of patients with PE scheduled for caesarean delivery who had a 15% increase of CI after a FC, in comparison with a control group of healthy pregnant patients. At baseline the patients in PE group showed higher Mean Arterial Pressure (MAP) and lower Stroke Volume Index (SVI). Fifteen patients were non responders (69% of the patients in PE group and 46% of the patients in control).

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Sunday, March 17, 2019

Journal of Biomedical Research and Reviews

Abstract

Introduction: #Mitochondrial disorders have a clinical and #geneticheterogeneity which often complicates the diagnostic process especially in critically ill patients. Exome sequencing can help to generate a definite diagnosis in a rather short time.
Case Presentation: A boy presented with inspiratory stridor, respiratory insufficiency, progressive #muscularhypotonia, poor head control and sucking, and #hypersomnia at three months of age. He got ventilator dependent and developed cardiomyopathy within weeks. The progressive multisystem disease leads to the suspicion of a mitochondrial disorder. As neither the clinical nor the metabolic changes or the diagnostic procedures performed seemed indicative of a specific mitochondrial disorder, we performed exome sequencing. This revealed a known #homozygousmutation (c.418G>A, p.Glu140Lys) in SCO2.

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Open Access Journals on Surgery

Abstract

#Alveolar osteitis (AO) is one of the most common complications after third molar surgery. Various risk factors has been determined as the etiology of AO. In addition, different preventive measures with promising outcome have been provided by researchers. The aim of the present review is to provide the most recent preventive measures to reduce the risk of developing AO following third #molar surgery.

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Journals on Cancer medicine

Abstract


Physicians are found to have a great and increasing amount of patients suffering from vertigo in their everyday practice. For the treatment of the balance disorders, a #vestibular training was introduced which played an influential role based on our study. Rehabilitation of patients having balance disorders is a known, major challenge for physicians. Vestibular #rehabilitation therapy (VRT) is an exercise-based treatment program designed to promote vestibular adaptation and substitution.

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Medical and Medicinal Journal

Abstract

Pregnane X receptor (PXR) is a nuclear receptor that exists in forms such as PXR1 and PXR2. Activated PXR1 #heterodimerizes with #retinoid Xreceptor to increase the transcription of #cytochrome P450 3A (CYP3A), a drug-metabolizing enzyme, by binding to the PXR biding site in nuclei. PXR2 is a splice variant of PXR1, which is localized to the nuclei and down regulates the #transcription of CYP3A by PXR1. The present study investigated the roles of PXR1 and PXR2 in the regulation of CYP3A11 expression in adult mouse organs and primary cultured hepatocytes. In the liver and small intestine, which show high expression of CYP3A11 mRNA, PXR1 mRNA was highly expressed while PXR2 mRNA expression was low. In the lung, kidneys, heart, and stomach, which show low expression of CYP3A11 mRNA, both PXR1 and PXR2 mRNA were expressed at high levels.

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Thursday, March 14, 2019

Journal of Scientific and Technical Research

Abstract

#Diabetes is a significant chronic disease, 424.9 million people worldwide are estimated to have diabetes in 2017,and this number is expected to increase to 628.6 million by 2045[1]. More and more patients with diabetes areaffected by other comorbidities, in fact, more than 40% of diabetic people have 3 or more comorbidities [2]. Another important aspect is that, as population ageing, health needs tend to become more complex, #multimorbidity, the co-occurrence of multiple diseases in the same patient, represents the mostrelevant featureamong older adults, with a prevalence from 55% to 98% [3]. Inevitably, the coexistence of chronic diseases isoften accompanied by #polypharmacy (daily intake of five or more drugs), that could createa frailty condition,poor adherence to #therapies, unknown Diabetes Quality of life (DDI) and inappropriatehospital admission, withsignificant implications on economic resources [4,5].

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Biomedical Research Articles


Abstract

Introduction: #Orthodontics has been advocating extraction as a treatment option for over a Century. Some concerns have been raised regarding dental extractions in orthodontics. Some clinicians suggested that extraction would lead to arch collapse resulting in a narrower arch width. Yet others have reported that extraction treatment to correct malocclusion will not result in arch narrowing compared with similar non #extractionprotocols. However, it is well accepted that extraction #treatment will involve changes in the arch dimensions.

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Open Access Journals on surgery

Abstract

The occurance of wound healing complications (WHCs) in the groin after vascular surgery is a serious medical and financial problem. Surgical site infections (SSIs) in the groin are reported with an incidence between 3% and 44%. In up to 6% deep groin infections involve the implanted prosthetic material. Since years case reports and clinical studies report on the effectiveness of the Closed #WoundTherapy Incision Negative Pressure (ciNPT) on wound incisions in the groin. The aim of this paper is to review the #clinicaldata of the ciNPT in the treatment of wound incisions in the groin after #vascularsurgery.

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Journals on Medical Drug and Theraputics

Abstract

Introduction: Almost all chemotherapy agents in use so far have a demonstrated cardiotoxic effect. New therapy protocols have significantly improved long term prognosis of patients with malignant tumors and helped increase their life span, but it also caused the increase of incidence of onset of #cardiotoxiceffects. The aim of this study was to examine whether preoperatively administered #chemotherapy agents influence the onset of #perioperativecardiovascularcomplications and to examine the influence of certain factors on the onset of cardiotoxic effects.

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Journals on Biomedical Science

Abstract

#Loeys-Dietz syndrome (LDS) is a connective tissue disease which develops due to the mutations in the genessynthesizing TFG-beta receptors. #Hypertelorism, cleft palate with bifid uvula and arterial/aortic aneurysms are the 3 basic elements of the disease forming a triad. Considering oral and #maxillofacialfindings in individuals with Loeys-Dietz syndrome, the responsibility of dentist is very important both in diagnosis of syndrome and in treatment. In the literature, there has been no publication of a dental approach to LDS and it is expected that this publication may be a guide to dentists for the syndrome.

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Wednesday, March 13, 2019

Biomedical Science Articles

Abstract

Background: The port site metastasis in #prostatecancer (PCa) after laparoscopic radical #prostatectomy (LRP) is an uncommon metastatic pattern of PCa.
Case presentation: We described an 81-year-old male patient who was admitted because of dysuria. Physical examination and imaging study indicated that the port site metastasis in PCa after LRP, and laboratory analysis revealed elevated prostate specific antigen (PSA). The diagnosis was established after #tumorresection, and then confirmed by pathology according to #immunohistochemicalstain

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Journal of Biomedical Research and Reviews


Abstract

#Researchers have been investigating new active principles from time tested plants which have been used as medicinal remedies through the ages by the native people. #Nyctanthus arbor-tristis (NA) Linn. is also very useful traditional medicinal plant of India, which has been cultivated for ornamental use and medicine as well. It is distributed throughout in sub-Himalayan regions and southwards to Godavari. Virtually each part of the plant has some medicinal value and is thus investigated extensively. It has been traditionally used to treat many ailments. We have tried to do a review of the existing literature and to present the entire work in a very comprehensive manner. We have also emphasized that more extensive research is warranted to proper exploration of this wonder medicinal plant as it is very cheap and widely distributed.

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Journals on Medical Casereports

Abstract

Under the current legislation EPC [1], an Environmental Risk Assessment (ERA) is mandatory to obtain Marketing Authorization for Veterinary Medicinal Products (VMP). ERAs for VMP, plant protection products, #biocides or industrial technical products, follow the General Protection Goals for ecosystems Devos It means that the ERA evaluates the environmental relevance of the active substances concentrations estimated in the different #environmentalcompartments taking into account the #ecotoxicologicaleffects on representative #organisms. Specifically, the guideline for VMP VICH GL 38, [3] mentions that “the overall target of the assessment is the protection of ecosystems”.

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Journals on Biomedical Imaging

Abstract

Objective: To assess the frequency of #anemia in mothers accompanying children admitted in General Medical Ward of The Children’s Hospital Lahore and to determine its association with the #growthparameters of their children under two years of age.
Methodology: Total 228 children admitted in General Medical Ward with acute illness along with their mothers were included in the study. Blood sample of their mothers for #Hb level was taken. Height and weight of children were plotted on WHO Growth Charts. Anemia was defined according to World Health Organization (WHO) as hemoglobin level of lt&;12 g/dL in non-pregnant women. Data was analyzed using SPSS version 20.

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Journals on Biomedical Engineering

Abstract

Background: The purpose of our work was to study the #epidemiological, clinical features and risk factors of #erysipelas in Internal Medicine. Methods: Retrospective study including 86 patients with erysipelas collected at our department of internal medicine between 2005 and 2016.
Results: There were 44 men and 42 women. The average age of our patients was 57.77. Erysipelas mainly affected the lower limbs in 95.3% of cases. Fever was present in 47.67% of cases. General underlying conditions were dominated by #diabetes (55.8%), obesity (37.2%) and overweight (31.4%). Loco-regional favoring factors were essentially represented by lymphedema (18.6%), venous insufficiency (12.8%) and #arteritis of the lower limbs (12.8%). A local site of entry was identified in 83.7% of the cases. The average number of total favorable factors was 3.12. Laboratory findings revealed #leukocytosis in 66.3% of cases and CRP elevation in 77.6% of the cases.

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Tuesday, March 12, 2019

Biomedical Research Articles

Abstract

Introduction: #Transcutaneouselectroneurostimulation has been used for a long time in the treatment of #neuropathicpain syndrome in type 2 diabetes mellitus. However, the effectiveness of this method in treating other manifestations of the distal polyneuropathy of the lower limbs as a sensory and motor deficiency has been little studied.
Objectives: To study the dynamics of sensory and motor deficiency against the background of the use of high-frequency low-amplitude TENS (HL TENS) and low-frequency high-amplitude TENS (LH TENS) in the treatment of distal #polyneuropathy of the lower limbs in patients with type 2 #diabetes mellitus.

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Journals on Vaccination

Abstract

#Cardiovascular disease (CVD) mortality is rising in many developing countries. There are many reasons for the mortality. In this study, we applied the IMPACT model to examine how much of the increase in CVD mortality in Beijing and Shanghai, two biggest cities in China. Also, we explored the changes of cardiovascular disease risk factors and assessed the influence of medication treatments on CVD mortality. The patients were enrolled from 2004 to 2010. The result showed that there was an increasing #mortalityrate of CVD by a negative age gradient in men and women after 45 years old. Most of the prevalence of CVD in different risk factor groups had an increased trend from 2008 to 2010, such as high blood pressure (BP), diabetes mellitus (DM), stoke, peripheral arterial disease (PAD) and coronary #heart disease (CHD).

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Medical and Medicinal Journal

Abstract

#Tenosynovitistuberculosis of the hand is a rare form of extra-pulmonary localization. we report an observation of localization of tuberculosis at the level of the clean sheath of the 5th finger of the hand.We emphasize the importance of the biopsy followed by an #anatomopathologicalexamination which remains the basis of the #diagnosis.An early diagnosis allows a well-defined medical treatment presenting complications.

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Journals on Biomedical Imaging

Abstract

This past Memorial Day honored our brave patriots who have lost their lives in the Iraq and Afghanistan War, but today we must not forget the noble obligation to help those still suffering. IAW-LI is hazardous for soldiers’ #health; this war-induced disease impacts multiple dimensions of everyday life, such as the ability to perform one’s job and the ability to exercise. We have conducted research on this disease and discovered soldiers suffering from this war-related #lunginjury have new onset asthma or fixed obstructed airways. We have reported titanium that is bound to iron in fixed #mathematical ratios of 1:7, which is extremely rare in nature, in the lungs of soldiers.

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Journals on Biomedical Science

Abstract

The purpose of this study is to develop the optimal method for heart decellularization using for tissue engineering. Several different chemical methods have been studied for decellularized tissues including heart. Nevertheless, there are not certain results about which combination of these methods may provide the best #transplantable, effective scaffolds. In this study, a new modified #decellularization method has been applied to heart including different concentrations of ionic and non-ionic detergents. To observe decellularization results #histologicalanalysis were performed. As a result, it was observed that chosen detergent solutions at low percentile concentrations and in short time duration showed efficient performance. Histological analysis indicated that samples were nuclei free in all groups.

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Biomedical Research Articles

Abstract #Preeclampsia (PE) is a pregnancy-specific syndrome characterized by maternal #cardiac output (CO) alterations and relat...