Correlation of Reduced Glutathione with Brest Cancer Using High Performance Liquid Chromatography by Mufeed Jalil Ewadh in BJSTR
Abstract
Breast cancer (BC) is a type of malignancy appeared in breast tissue,
occurs in both premenopausal and also in postmenopausal women’s.
Glutathione (GSH) is a tripeptide that is found intracellularly in high
concentration, being the most abundant low molecular mass thiol. A total
of 80 patient with (BC) divided in two groups, first group (n=40) women
with breast cancer without chemotherapy, second group (n= 40)
women with breast cancer with chemotherapy. The control group (n= 40)
apparently healthy women’s matched with patient group. Women
with (BC) have a significant lower serum level of (GSH) than those who
are not diseased and even than those who received chemotherapy (p˂
0.05). So, this lead to a conclusion that; breast cancer women have low
level of GSH and increased upon administration of chemotherapy. The
objective of this study is to assess GSH status in women’s BC receiving
chemotherapy treatment.
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