Adverse
Health Consequences of Dietary Advanced Glycation End Products (ages)
and Inhibitory Effects of Natural Ingredients on Ages by Qingrong Huang in BJSTR
Abstract
Dietary advanced glycation end products (AGEs) may result in various
adverse health consequences, such as inflammation, cancer, liver
diseases, obesity, cardiovascular diseases, diabetes, proteostatis
impairment and memory decline. Natural ingredients may be a promising
strategy to inhibit AGEs generation and ameliorate health risks of AGEs.
The mechanisms involved in inhibition of AGEs with use of natural
ingredients include antioxidant activity, reactive carbonyl trapping,
and suppressing pathways of RAGE (receptor of advanced glycation
end product), MAPK (mitogen-activated protein kinases) and NF-κB
(nuclear factor-kappa B).This mini review summarizes the present
understanding of the adverse impact of AGEs on health and the inhibitory
effect of natural ingredients on AGEs.
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