Abstract
Hypo fractionated schedules deliver greater than 2 Gy of radiation
per fraction while reducing the total cumulative dose through reducing
the
number of treatment sessions. In breast cancer, radiotherapy is
indicated for all patients after breast conservative surgery and for
patients after
mastectomy if indicated. Radio biologically, this approach appears to be
as effective and safe as the conventional regimen in both experimental
and clinical studies, based on the LQ model, when the α/β ratio of the
tumor is similar to that of the surrounding normal tissue, the hypo
fractionated regimen may be equally or potentially more effective than
that of the conventional one. Conventional fractionated radiotherapy has
been challenged by patient’s compliance, travelling, unplanned
interruption and others compared to hypo fractionated regimen which
would be
more appealing and convenient to the patients, and financially, this
treatment schedule is useful in reducing the radiotherapy costs. It is
thought
that if these schedules found to have an equivalent loco regional
control, survival and cosmoses to standard conventional schedules, it
would be
a revolutionary breakthrough in the future for breast cancer management
as if these schedules are established, it will be a major breakthrough
as it will decrease the waiting list and the number of hospital visits
in several cancer centers especially in the developing countries.
Postmastectomy Hypo Fractionated Radiotherapy: May be a Breakthrough in Breast Cancer Management by Bader Abdelmaksoud in BJSTR
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