#Anti-Microbial Peptides and Their Speculative Role in Periodontitis by Gabriela Fernandes in BJSTR
Abstract
Antimicrobial Peptides (AMPs) are present in the oral cavity in the
form of defensins and human cathelicidin LL-37 (from neutrophil
granules) and histatins along with pdefensins 1 and 2 (from salivary
glands and gingival epithelial cells). The oral micro flora organisms
that
play an important role in the pathogenesis of periodontal disease are
opportunistic pathogens, that are highly proteolytic and this activity
is
known to contribute to nutrient acquisition, tissue destruction and
de-regulation of inflammatory responses. Furthermore, the production of
proteases enables oral bacteria to evade killing by antimicrobial
peptides, thus contributing to the virulence of such opportunistic
pathogens,
which could have implications for the use of antimicrobial peptides as
therapeutic agents to treat periodontal disease. Hence, this review
summarizes the suggestive role of AMPs in periodontal disease.
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