Design, Development and Characterization of Sustain Release Matrix Type Tablet of Cinnarazine by Suman Gehlot in BJSTR
Abstract
The objective of this study was to design and evaluate oral sustain
release drug delivery system for Cinnarazine using hydrophilic polymers
such as and HPMC (K100M), PVP (K) batches. Four batches were prepared by
using HPMC (K100M) in drug: Polymer ratio of 1:1, 1:1.5, 1:2,
1:3 and five batches using PVP (K) in ratios of 1:1, 1:1.25, 1:1.5,
1:1.75 and 1:2. Further formulation F9 was modified by varying the
ratios of
diluents i.e F10, F11, F12 and F13 to check the effect of diluents on
drug release. Matrix tablets were prepared by wet granulation method and
were evaluated. Among the formulations studied, formulation F9
containing HPMC K100M (1:2) showed sustained release effect for 20 h
with
cumulative percent release of 88% similar to that of the research listed
drug. The kinetic treatment showed that the optimized formulation
follow first order kinetic with release exponent (n) 0.579 and having
good stability as per ICH guidelines. Key Words: Sustained release,
Hydrophilic gums, HPMC (K100M)/ (PVP (K), Magnesium stearate, Lactose
and drug Cinnarazine.
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