Abstract
The eye is a highly complex organ in terms of structure and
function. It is a very sensitive organ, the function of which may
be affected even with mild insult to its homeostasis, due to direct
injury or due to other local or systemic diseases Scountzou [1]. The
practice of ophthalmology, whether on humans or animals, can be
reduced to the simple goal of getting the right pharmacological
agent at the appropriate therapeutic dose to the target ocular tissue
by a method that does not damage healthy tissue. In ocular disease,
however, this simple goal becomes more challenging because of
the highly sensitive ocular tissues (e.g., the uveal tract and retina)
and the presence of tissue barriers to drug penetration, namely the
lipophilic corneal epithelium, the hydrophilic corneal and sclera
stroma, the conjunctival lymphatics, choroidal vasculature, and the
blood-ocular barriers Weiner & Gilge [2].
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