#Oral Submucous Fibrosis: the #Soft Tissue Marble of Asia by Karthik D Yadav in BJSTR
Abstract
Oral squamous cell carcinoma is the sixth most common
malignant neoplasm worldwide. Each year it accounts for more than
300,000 cases worldwide. The 5-year survival rate for OSCC has
remained at approximately 50% for the past several decades [1].
The impact of oral cancer is such that the disease and its treatment
bring a heavy financial burden to both the social resources and the
patient’s family with psychological stress affecting the quality of life
[2]. It develops through a multistep process of genetic, epigenetic
and metabolic changes resulting from exposure to carcinogens,
with initially the presence of a precursor/pre-cancer such as oralleukoplakia, oral erythroplakia oral submucous fibrosis. The most
frequently reported etiological agents being tobacco, alcohol,
chewing of betel quid containing areca nut [3]. The global incidence
of oral submucous fibrosis is estimated at 2.5 million individuals.
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