Abstract
#Matrixmetalloproteinases (MMPs) belong to family of #proteolyticenzymes that cause degradation of extracellular matrix macromolecules,
including interstitial and basement membrane collagens, #fibronectin,
laminin and #proteoglycan core protein by secreting enzymes in latent
form;
which later gets activated in the pericellular environment by disruption
of a Zn++ cysteine bond. There is much evidence for the role of matrix
#metalloproteinases in the destructive processes of #periodontaldisease distinguishing them as a viable target for a chemotherapeutic approach.
The use of a host modulatory agent such as a matrix metalloproteinase
inhibitor can assist with conventional treatment for #periodontitis and,
when used adjunctively, can enhance and make clinical therapeutic
responses more predictable in the more susceptible patient.
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