Abstract
The #liver has the specific capacity to regulate its growth and
repair. The healing process in the liver is characterized by the
#proliferation
of all existing cell lines within the liver, including hepatocytes,
#epithelialcells that line the #canaliculi, endothelial cells, and
Kupffer and HSCs
cells. The liver also contains “stem” cells or liver progenitor cells
(oval cells in rodents) that can be activated by liver damage. #Ovalcells are the
progeny of stem cells. They can divide rapidly but in contrast to stem
cells do not possess the ability to self-renew. Oval cells have the
potential
to generate more than one differentiated cell type but cannot be
serially transplanted. During liver regeneration, oval cells are
essential at
forming a second line of defense. In this article, we review some
aspects of oval cells, characters, role in normal regenerative process
as well as
its role in liver diseases and #malignancy besides its potential
applications as source of cellular therapy.
#OvalCells: Potential Role in #LiverRegeneration by Hussein Abdellatif in BJSTR
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