Pediatric Inflammatory Bowel Disease: A Review of Immune #Homeostasis and #Genetics with an Emphasis on the IL-10 Pathway by Zhenwu Lin in BJSTR

Abstract

Inflammatory #boweldisease (IBD) is an auto-immune condition characterized by chronic #gastrointestinalinflammation. The incidence of #pediatricIBD, particularly the early onset disease subtypes, has been increasing internationally. In contrast to later-onset IBD, recent literature indicates that early-onset (between 3 - 5 years) and very early-onset (between 0 - 2 years) patients present with a more severe and #aggressivedisease. A comprehensive review of the literature indicates that the gut microbiome, which is heavily influenced in the early life, is reduced in IBD patients and hence plays a role in regulating #gastrointestinalhomeostasis. While many genes have been confirmed to be associated with IBD, only a portion of those genes have been shown to cause pediatric IBD.

https://biomedres.us/abstracts/BJSTR.MS.ID.000713.php 

https://biomedres.us/pdfs/BJSTR.MS.ID.000713.pdf 

https://biomedres.us/fulltexts/BJSTR.MS.ID.000713.php 

Pediatric Inflammatory Bowel Disease: A Review of Immune #Homeostasis and #Genetics with an Emphasis on the IL-10 Pathway by  Zhenwu Lin in BJSTR