Abstract
#Caninecoronavirus (CCoV) is an enveloped, single-strand #RNA
virus belonging to the #Alphacoronavirusgenus in the #Coronaviridae
family Pratelli [1,2] Despite their labile nature, RNA viruses are
able to rapidly adjust to negative pressures of immune system,
generating novel strains that might have selective advantages
over parental genomes. As a consequence of the high mutation
frequency, in the last years CCoV has evolved and new #genotypes/
types were identified, raising several questions regarding the
biology of these viruses Pratelli, Cirone and Pratelli [2, 3]. CCoVs are
responsible for enteritis in dogs of all breads and ages and clinical
signs may vary from mild to severe #gastroenteritis in young pups.
Though fatal infections are unusual unless mixed infections with
other pathogens occur or in the presence of overcrowding and
unsanitary conditions Pratelli et al., [5], the virus is an important
pathogen responsible for epizootics in dog population Pratelli
[2]. Recently, a CCoV type 2a pantropic variant was identified in a
systemic fatal disease in young dogs Buonavoglia et al., [6], and a
subsequent experimental study has raised important questions on
the pathobiology of CCoVs, demonstrating that the new virus was
able both to infect CCoV-seropositive dogs and to induce clinical
signs irrespective of the viral dose administered in the challenged
dogs Decaro et al. [4].
The Polarity of Entry and Release of Canine #Coronavirus From #EpithelialCells by Annamaria Pratell in BJSTR
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