Abstract
Aim: Aggregatibacter #actinomycetocomitans,a gram negative
facultative #anaerobiccoccobacilli is the main etiologic agent in the
#pathogenesis of localized aggressive periodontitis. So considering this,
the aim of the present study was to study the sensititivity of the
organism
to various drugs in vitro.
Materials and Methods: Microbial plaque samples from 40
patients who were diagnosed to have localized aggressive #periodontitis
were cultured anaerobically to confirm Aggregatibacter
actinomycetocomitans. Doycycline, amoxicillin, #kanamycin, norfloxacin,
#ciprofloxacin,
gentamycin, netilmycin co-trimoxazole, metronidazole, and ampicillin and
cephazolin antibiotic sensitivity discs were placed in the culture
plate. The plates were incubated anaerobically at 37 degree Celsius for
48 hours. At the end of the duration the plates were opened and the
sensitivity of the organism to various drugs was examined.
Results: The antibiotic sensitivity test showed that the
organism was found to be highly sensitive to tetracycline, #amoxicillin,
metronidazole,
kanamycin, norfloxacin, ciprofloxacin, #gentamycin and netilmycin. It was
moderately sensitive to Co-Trimoxazole and resistant to #ampicillin and
Cephazolin.
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