Abstract
Reactive blue 2 is an a specific #antagonist of the ATP P2X and P2Y
receptors that are ligand-gated ion channels widely distributed in
the organism and that serve as control of excitability of their host
cells. Due to the known involvement of ATP in inflammatory and pain
processes, we have evaluated the pro-inflammatory effect of reactive
blue 2 in the paw oedema induced by carrageenin in rats. Reactive blue
2 did not by itself induce paw oedema but enhanced all phases of the
inflammatory response induced by #carrageenin. In the first phase of the
oedema (0-1 h), compound 48/80, but not the serotonin and histamine
receptor antagonists cimetidine, cyproeptadine and diphenydramine,
counteracted the pro-oedema effect of reactive blue 2. The second phase
(0-2 h) of carrageenin+reactive blue 2 was markedly antagonized
by hexadimethrine, a heparin antagonist. The late phase, characterized
by prostaglandins involvement was partly antagonized by the dual
antagonist of cycloxigenase and lipoxygenase BW 755 and by
dexamethasone, but not by indomethacin. The modulating effect of
reactive blue
2 on ATP via other autacoids such as heparin is probably responsible on
its pro-inflammatory effects.
Pharmacological Analysis of the Potentiation of #Carrageenin-Induced Paw Oedema by Reactive Blue 2 by Stefano Evangelista in BJSTR
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