Abstract
a) Background: #Pre-eclampsia is one of the most common #complications of pregnancy and a significant cause of #morbidity and
mortality
for both the mother and the fetus, especially in developing countries.
Despite considerable research, its cause or causes remain unclear.
b) Objective: To determine any significant association between pre-eclampsia and lipid profile changes.
c) Methodology: A prospective comparative cross-sectional
study was carried out among 70 pre-eclamptic and 70 normotensive
pregnant
women from Aminu Kano Teaching Hospital, Kano. The control subjects were
matched to each case for maternal age, gestational age and body
mass index. A structured questionnaire was administered and relevant
socio-demographic information was obtained. #Clinicalcharacteristics including blood pressure were measured and urinalysis performed. Fasting
serum lipids were collected and analyzed for total #cholesterol,
#triglyceride, very low density lipo-protein (VLDL), low density
#lipo-protein(LDL) and high density lipo-protein(HDL)
d) Results: The study showed a significantly higher level of
VLDL, LDL and triglyceride among the pre-eclamptic group compared to the
normotensive (P< 0.001), while HDL was significantly decreased among
the pre-eclamptic group in contrast to the normotensive (P = 0.028).
There was statistically significant difference in all the lipid
fractions in the 3rd trimester and a significant positive correlation of
VLDL and
triglyceride with pre-eclampsia (P= 0.019, P=0.020, respectively).
e) Conclusion: This study showed that pre-eclampsia is
associated with increased levels of VLDL and triglyceride and decreased
levels of
HDL and this is more evident in the 3rd trimester. This association may
be important in understanding the pathologic processes of the disease
and in developing strategies for its prevention and early diagnosis.
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