Abstract
The reported inhibitory effects of the natural products vanillin and
5-hydroxymethylfurfural prompted us to assess the anti-polymerization
activities of several structurally related aromatic #aldehydes and
#carboxylicacids. In addition to vanillin and #5-hydroxymethylfurfural,
eleven
more structurally related aromatic aldehydes and carboxylic acids
including 2,4-dihydroxy benzaldehyde, furfural, 3-furfural,
5-methylfurfural,
vanillic acid, 2-hydroxy-3-methoxy-benzoic acid, homovanillic acid,
mandelic acid, 4-hydroxy-3-methoxy-mandelic acid, 4-bromo-mandelic acid
and4-trifluromethyl-mandemic acid are evaluated for activity using our
newly reported high throughput kinetic assay designed to study sickle
cell hemoglobin polymerization kinetics. Several of the tested compounds
exhibited promising anti-polymerization activities, comparable to
that of vanillin and 5-hydroxymethylfurfural, including #homovanillicacid, #mandelicacid, 3-hydroxy-3-methoxymandelic acid, and 3-furfural.
The structure activity relationship of all tested compounds is included.
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