Combinatorial Regulatory Networks Provide Novel #Biomarkers for Diagnosis and #Therapeutics by Esra Gov in BJSTR

Abstract

One the most important discoveries of the #post-genomicerais that a large fraction of the #genome transcribes a #heterogeneous population of non-coding RNAs (ncRNA). NcRNAs shorter than 200 #nucleotides are usually identified as short/small ncRNAs - examples include PIWI-interacting RNAs, small interfering RNAs, and microRNAs (miRNAs)-whereas those longer than 200 nucleotides are classified as long ncRNAs (lncRNAs). They are part a crucial role in RNA silencing and post-transcriptional regulation of gene expression [1]. These molecules are emerging as important regulators of cellular process, such as development, differentiation, and #metabolism [2]. Long and short #ncRNAs not only regulate developmental processes and cell physiology, but also involved in disease states, host-pathogen interactions, and a variety of stress responses [3]. Transcriptional regulation of #geneexpression is often the prior process due to response of system changes, wherein the information contained in a genome is converted and then ultimately used to produce the proteins required for a given response.

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Combinatorial Regulatory Networks Provide Novel #Biomarkers for Diagnosis and #Therapeutics by Esra Gov in BJSTR