Abstract
Sweet Basil (#OcimumbasilicumLinn.) has a variety of #therapeuticproperties, including antimicrobial activity. This study aimed to
determine the antibacterial activity of the major chemical components in
the crude extract against #methicillin resistant #Staphylococcusaureus
(MRSA) isolated from the clinical specimens. TLC and column
chromatography resulted in the separation of two major compounds. On the
basis of the spectral data, they were identified as #linalool (1) and
1,8-cineole (2). #Antibacterialactivity of crude extract and isolated
compounds
was evalusted by disc diffusion, MIC and MBC against 9 multi-drug
resistance S. aureus isolated from clinical specimens. The crude extract
and
isolated compounds exhibited an excellent antimicrobial activity at a
dose level of 34.5 mg/disc for disc diffusion method. The crude extract
and linalool showed higher activity against tested MRSA with MIC
(<0.09 mg/ml) and MBC (≤ 0.09 to 0.38 mg/ml) than 1,8-cineole. The
results
suggest once again that the antimicrobial activity of the crude extract
and major isolated compounds, linalool and 1,8-cineole are a resultant
of the #antibacterialproperty against MRSA.
For more Biomedical open access journals please click on https://biomedres.us/
For more Research Articles on BJSTR
https://biomedres.us/fulltexts/BJSTR.MS.ID.000910.php
Major Compounds from Ocimum Basilicum l. and their #AntimicrobialActivity against Methicillin-Resistant #StaphylococcusAureus by Thongchai Taechowisan in BJSTR
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.