Abstract
#Mesenchymalstemcells (MSCs) have been reported to possess
modulatory effects on various types of cancers as well as
#immunomodulatoryproperties, which have intrigued many researchers. Over the past two
decades, there has been a focus in literature on the interaction
between MSCs and #leukemias. However, the interactions between the MSCs
and leukemic cells, in particular the k562 cells, have not been
well documented. The aim of this study was to demonstrate the
interactions between human #bonemarrow-derived MSCs (hBM-MSCs) on
a chronic myeloid leukemic cell line (K562 cells). Co-culture of K562
cells with the hBM-MSC increased the viability of these cells in
noncontact
and contact co-culture conditions. The same was observed when the K562
cells were cultured in hBM-MSC conditioned medium.
Transmission #electronmicroscopy (TEM) of K562 cells co-cultured with
hBM-MSCs showed significant ultra-structural observations consistent
with biochemical assays performed. The findings suggest that although
cell-to-cell interaction is required for effective modulatory effect to
occur, soluble substance secreted by the hBM-MSCs may also be able to
emulate similar effects.
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