Abstract
Attention deficit #hyperactivitydisorder (ADHD) and #autism spectrum
disorder (ASD) are classified as #neurodevelopmentaldisorders by DSM-5.
ADHD is characterized by the behavioral symptoms including inattention,
hyperactivity and impulsivity and also by moderate-to-severe academic
and social impairment. In addition, ASD is characterized by impaired
social interaction, impaired verbal communication, and repetitive
behaviors. Brain #monoamines and their neuroactive metabolites are
thought to play key roles in neurodevelopmental pathology, but the
specifics are still unknown. Here we provide the first evidence of a
correlation between inattention, higher levels of 3-methoxy-4-
#hydroxyphenylglycol (MHPG), and lower levels of #homovanillicacid (HVA);
between hyperactivity/impulsivity, higher levels of HVA, and lower
levels of MHPG; and between autistic symptoms, higher levels of MHPG,
and lower levels of 5-hydroxyindoleacetic acid (5-HIAA).
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