Biomedical Journal of Scientific Research

Abstract

We report here the clinical effects of the sustained release of basi #fibroblast growth factor (bFGF) from #gelatinhydrogel in cases of periodontal disease with infrabony defects. Patients with moderate to advanced #periodontitis were treated with a #mucoperiosteal flap operation. At the time of #surgery, each bone defect was filled with gelatin hydrogel incorporating bFGF (bFGF/gelatin hydrogel). Probing pocket depth (PPD), clinical attachment level (CAL), and radiographic bone level were evaluated before treatment and at 3, 6, and 12 months after treatment. There were significant improvements in #clinicalparameters after #treatment. There were no adverse effects during the treatment period. Topical application of bFGF/gelatin hydrogel may promote periodontal regeneration in cases of #chronicperiodontitis with infrabony defects.

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Periodontal Regeneration Using Gelatin Hydrogels Incorporating Basic #Fibroblast Growth Factor by Goichi Matsumoto in BJSTR