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Abstract

Background: Memory loss is a most disabling feature of #cognitivedisorders which disrupts the life styles of patients and equally affects the patient caregivers. Management and treatment of memory loss is highly challenging as no potential remedy is available at present for the complete cure. In this study, #antiamnesic and neuroprotective efficacy of methanolic extract of dried leaves of Mimusops Elengi Linn. (MEE) was investigated in mice.

Methods: Elevated plus maze and Morris water maze were used for assessment of acquisition and retention. Scopolamine (0.4mg/kg, i.p.) and #diazepam (1mg/kg, i.p.) induced amnesia were the exteroceptive models.

Results: MEE (100 and 20mg/kg, p.o.) significantly improved acquisition and retention in amnesic mice. MEE also exhibited reversal effects in aged mice (aging induced amnesia). MEE significantly increased acetyl #cholinesterase inhibitory activity in the mouse brain. M. Elengi exhibited potential #neuroprotectiveeffects.

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Antiamnesic and #NeuroprotectiveEffects of Leaves of Mimusops elengi on Brain Aging and Chemically Induced #Amnesia in Mice by Hanumanthachar Joshi in BJSTR