Abstract
Background: Memory loss is a most disabling feature of #cognitivedisorders which disrupts the life styles of patients and
equally affects
the patient caregivers. Management and treatment of memory loss is
highly challenging as no potential remedy is available at present for
the
complete cure. In this study, #antiamnesic and neuroprotective efficacy
of methanolic extract of dried leaves of Mimusops Elengi Linn. (MEE) was
investigated in mice.
Methods: Elevated plus maze and Morris water maze were used for assessment of acquisition and retention. Scopolamine (0.4mg/kg, i.p.)
and #diazepam (1mg/kg, i.p.) induced amnesia were the exteroceptive models.
Results: MEE (100 and 20mg/kg, p.o.) significantly improved
acquisition and retention in amnesic mice. MEE also exhibited reversal
effects in aged mice (aging induced amnesia). MEE significantly
increased acetyl #cholinesterase inhibitory activity in the mouse brain.
M. Elengi
exhibited potential #neuroprotectiveeffects.
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