#Coating of Single Cells towards Biomedical Applications by Sung Ho Yang in BJSTR

Abstract

In 2002, a pioneering work on single cell coating with macromolecules through layer-by-layer (LbL) method was published in Langmuir [1]. Yeast cells were alternately coated with #cationic and anionic #macromolecules. Even after coating, the cells still survived. Inspired by the work, multilayered macromolecules have been used for coating various types of microbial cells and #endospores [2]. Although the survival of #microbialcells in the artificial coat was interesting of itself, the impact of works was under evaluated in the biomedical fields because the method was limited to microbial cells and the macromolecular coating had no particular roles. The two limitations have been gradually solved by developing functional coating materials and applying the method to mammalian cells. The function of coating materials was mainly improved by shifting from organic macromolecules to inorganic materials, in other words, from soft to hard materials Tang et al. [3-6]. crystalized calcium phosphate on the #multilayer-coatedyeastcells, leading to rigid artificial shells [7]. Choi et al. synthesized silica on the multilayer-coated yeast cells in a #biomimeticmanner, which was the first report on coating living cells with covalent bonded inorganic materials [8-10]. And chrollera cells were coated with Titania using #catalyticpeptides [11].

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#Coating of Single Cells towards Biomedical Applications by Sung Ho Yang in BJSTR