Abstract
Weight loss is frequent in patients with #Alzheimer’sdisease (AD), even in early disease stage [1]. Therefore, weight loss is
a significant predictor of mortality in AD patients. The etiology
of AD-associated weight loss is #multifactorial, occurring when
energy expenditure exceeds energy intake [2]. In addition, the
loss of skeletal muscle protein, one of the causes of weight loss,
occurs by an imbalance between the rate of protein #synthesis and
degradation [3]. Therefore, many studies have examined energy
expenditure, energy intake, body composition, and other #geneticfactors in relation to weight loss in AD patients. This mini-review
further discusses the factors leading to weight loss in AD #patients.
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