Energy and Skeletal Muscle Protein Metabolism Balance and Weight Loss in Patients with #Alzheimer'sDisease: a Mini-Review by Tomiyo Nakamura in BJSTR

Abstract

Weight loss is frequent in patients with #Alzheimer’sdisease (AD), even in early disease stage [1]. Therefore, weight loss is a significant predictor of mortality in AD patients. The etiology of AD-associated weight loss is #multifactorial, occurring when energy expenditure exceeds energy intake [2]. In addition, the loss of #skeletalmuscle protein, one of the causes of weight loss, occurs by an imbalance between the rate of #proteinsynthesis and #degradation [3]. Therefore, many studies have examined energy expenditure, energy intake, body composition, and other genetic factors in relation to weight loss in AD patients. This mini-review further discusses the factors leading to weight loss in AD patients.

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Energy and Skeletal Muscle Protein Metabolism Balance and Weight Loss in Patients with #Alzheimer'sDisease: a Mini-Review by Tomiyo Nakamura in BJSTR