#Metabolomics Used in Herb-Induced #LiverInjury by Geng Xingchao in BJSTR

Abstract

#Metabolomics [1]. As a formidable tool, is usually used to systematically assess the molecular responses of living systems to all external stimuli, characterize #pathologicalstates, diagnostic information and mechanistic insights into biochemical effects of drugs, based on global metabolite profiles in biological samples [2]. #Massspectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, two major analytical platforms, with visualization software, have driven forward the discipline of metabolomics. Traditional Chinese #Medicine (TCM) with its focus on herbal use is popular and appreciated worldwide with increased tendency [3,4]. And treatment was perceived as fairly safe but discussions emerged more recently as to whether herb-induced liver injury (HILI) from #herbal TCM is a major issue. The multi-component and multi-target nature of TCM makes toxicological research far more complex than that of chemical drugs. Looking for rapid and sensitive biological toxicity effect evaluation technology has become a major problem urgently to be solved in current TCM safety evaluation. Metabolomics can further be employed as a perfect approach to link the gap between TCM and molecular #toxicology. We reviewed the applications of the metabolomics with two major analytical platforms for HILI researches.

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Metabolomics Used in Herb-Induced Liver Injury by Geng Xingchao in BJSTR