Possible Improvement of Liver Steatosis Associated with Elevated Creatine Phosphokinase Level Due to Subclinical Hypothyroidism by #ThyroidHormone Replacement Therapy by Ken Sato in BJSTR

Abstract

A 71-year-old man suffering from non-alcoholic fatty liver disease, diabetes and #dyslipidemia was hospitalized for elevated #creatinephosphokinase levels. Discontinuation of antihyperlipidemic agents and #rehydration could not normalize creatine phosphokinase levels. Findings of liver biopsy were compatible with non-alcoholic #steatohepatitis. Based on the detailed evaluations, he was diagnosed as hypothyroidism. Thyroid hormone replacement therapy gradually improved his thyroid function and creatine phosphokinase levels. Notably, the repeated liver biopsy after the therapy showed histological improvement of #steatosis. We should suspect “subclinical” hypothyroidism in case of unexplained elevation of creatine phosphokinase levels during the course or at the onset of non-alcoholic fatty liver disease / nonalcoholic steatohepatitis.

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Possible Improvement of Liver Steatosis Associated with Elevated Creatine Phosphokinase Level Due to Subclinical Hypothyroidism by #ThyroidHormone Replacement Therapy by Ken Sato in BJSTR