Abstract
Background: Gallbladder cancer is a highly #ethal pathology,
mainly due to late #diagnosis and poor therapeutic alternatives.
Epigallocatechin
gallate (EGCG) has been reported as a cancer #chemoprophylaxis, but its
low stability and bioavailability limit its utility. The purpose of this
study was to define the optimal process conditions by nano spray drying
for EGCG microencapsulation using gum arabic and #maltodextrin as a
wall material and to test its chemopreventive action efficiency on #gallbladdercancercell lines (GB-d1).
Methods: For microcapsule production using a Büchi nanospray
dryer, an experimental Taguchi design was applied using a L4(23) matrix.
The effects of #cytotoxicity and reactive oxygen species (ROS) production
on GB-d1 cells in the presence of #microencapsulated EGCG were
assessed.
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