Abstract
#Tumournecrosis factor (TNF)-related #apoptosis-inducing ligand
(TRAIL) is a promising anti-#cancer agent due to its selective killing
of cancer cells, sparing the vital normal cells. Despite its great
potential in cancer treatment, its clinical application has been
hampered by
the cancer resistance. Various strategies have been developed to
overcome resistance towards TRAIL-induced apoptosis which include the
combinational therapy of TRAIL with #epigeneticdrugs, #chemotherapy drugs
and the #autophagyinhibitors. To heighten the therapeutic outcome,
the personalized medicine based on #biomarker screening could serve as a
novel strategy in tailoring the combinational therapy of TRAIL and
sensitizer for targeted cancer therapy in the near future.
For more Biomedical Open Access Journals please click on https://biomedres.us/
For more Biomedical Scientific Research Articles on BJSTR
Trailing TRAIL Resistance for Targeted #CancerTherapy by Ngai Siew Ching in BJSTR
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