Biomedical Science Articles

Abstract

Trained innate #immunity attracts more and more attention in recent years. Innate immune memory is observed in natural killer cells, #monocytes and #macrophages after being trained by certain antigens and non-specific strong immune responses may occur after the secondary stimulation. Mechanism studies reveal that induction of trained innate immunity depends on #epigenetic reprogramming. In this article, the phenomenon, mechanisms and possible applications of the trained innate immunity are reviewed.

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Trained Innate Immunity: New #Immunological Memory Mechanisms by Yan Wang in BJSTR