Free Medical Journal

Abstract

Results of recent studies showed that the #insulin growth factor (IGF) pathway might be implicated in the development of epithelial #ovariancancer (EOC). Moreover, it was demonstrated that EOC cells with high #microsatellite instability (MSI-H; non19/non19) accumulate #mutations in the IGF-1 #gene. The aim of our study was to analyses the (CA)n repeats polymorphism in the P1 promoter region of the IGF-1 gene in EOC and healthy volunteers.For identification of (CA)n repeats PCR and DNA sequencing were utilised. Serum blood concentrations of IGF-1, IGFBP-1, IGFBP-3 were determined with ELISA. IGF-1 expression was assessed by #immunohistochemicalanalysis. According to the obtained results biological samples were classified as microsatellite instability-high (MSI-H), MSI low (MSI-L) and microsatellite stable (MSS).

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IGF-1 Gene P1 Promoter #Polymorphisms Influence Predisposition to Epithelial Invasive #OvarianCancer by Maria Wolun Cholewa in BJSTR