Abstract
#Inflammatory bowel disease (IBD) is a chronic, relapsing, #idiopathic inflammation of the gastrointestinal tract characterizing chronic#colonic inflammation of GIT. This results from the interaction between
the various components of the mucosal immune system and the
#microenvironment. It is considered as an auto immune disease (AID)
involving various factors like immune dysregulation, genetic
predisposition,
dysbiosis of commensal flora and environmental factors. ATP-binding
cassette (ABC) #transporters are a large superfamily of #membrane proteins
with various functions and are also expressed on apical lining of
intestine. They utilize the energy from ATP hydrolysis for import and
export
of from ATP hydrolysis for import and export of substrates.
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