Abstract
Heat shock protein 90 (Hsp90) is a molecular chaperone, indispensable
for the stability and function of several conditionally activated or
expressed signaling proteins. Hsp90 inhibitors can cause the
inactivation, #destabilization and eventual degradation of HSP90 client
proteins by
interacting predomently with a singular #molecular target. Hsp90 #inhibitors are unique in such a way that even though they are directed
towards
a specific molecular target, they simultaneously attenuate multiple
signaling pathways that frequently interact to promote cancer cell
survival.
HSP 90 #inhibitors displayed promising #antitumoractivity in #preclinicalmodel systems. The herbs containing alkannin (3) and shikonin (4) are
used in the treatment of measles, smallpox, sores, ulcers and wounds and
skin eruptions in traditional Chinese medicine (TCM).
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