Abstract
Multiple #myeloma is the second most common #haematologicalmalignancy – though multiple effective therapeutic options exist for
disease control – cure of myeloma still remains the exception. Our
present therapeutic approach is founded on apoptosis induction in
tumor cells by various different stimuli, most commonly by DNA
damage, oxidative or #endoplasmic reticular (proteomic) stress.
Effective treatment of relapsed and/or refractory disease rarely
provides long term disease control mainly due to development of
resistance to pharmacological induction of apoptosis pathways.
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BCL-2 Inhibition in the Treatment of Multiple Myeloma by Gabor Mikala in BJSTR
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