Abstract
Due to many factors such as drug purity, #thermodynamicstability,
manufacturability, and ease of handling, until now the #activepharmaceuticalingredients (APIs) in the pharmaceutical industry
are mainly in solid or crystalline forms. However, these forms of
APIs usually suffer from low solubility, low biological permeability,
and polymorphic conversion, which lead to unsatisfactory #bioavailability
and low efficiency of drugs. Active pharmaceutical #ionicliquids (API-ILs) are expected to solve these problems. Moreover,
many investigations confirm that API-ILs can retain or result in
increasing #bioactivity of the involved active pharmaceutical ingredients
(APIs) [1-3].
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