#Prolongedcoldstorage (CS) of kidneys before #transplantation (Tx) is
associated with poor renal outcome after Tx. We recently showed
that, in rats, renal function was severely compromised in kidneys
subjected to CS and then TX (CS/Tx), as compared to those transplanted
without CS (autotransplantation, ATx). Evaluation of whole-kidney
extracts from our rat model showed a subset of #proteins induced after
CS/
Tx; this study examined those proteins. Kidneys of male Lewis rats
exposed to CS/Tx were compared those exposed to ATx (i.e., removed and
immediately reattached) or sham. Our study using mass spectrometry
identified #albumin in extracts of kidneys that underwent sham; albumin
levels modestly increased after ATx and dramatically increased after
CS/Tx.
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