Abstract
Pregnane X receptor (PXR) is a nuclear receptor that exists in forms
such as PXR1 and PXR2. Activated PXR1 #heterodimerizes with #retinoid Xreceptor to increase the transcription of #cytochrome P450 3A (CYP3A), a
drug-metabolizing enzyme, by binding to the PXR biding site in nuclei.
PXR2 is a splice variant of PXR1, which is localized to the nuclei and
down regulates the #transcription of CYP3A by PXR1. The present study
investigated the roles of PXR1 and PXR2 in the regulation of CYP3A11
expression in adult mouse organs and primary cultured hepatocytes. In
the liver and small intestine, which show high expression of CYP3A11
mRNA, PXR1 mRNA was highly expressed while PXR2 mRNA expression
was low. In the lung, kidneys, heart, and stomach, which show low
expression of CYP3A11 mRNA, both PXR1 and PXR2 mRNA were expressed
at high levels.
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