Abstract
#Intracellularsodiumion functions as an initiating signal for #organregeneration in lower vertebrates, such as amphibians, Intracellular
sodium ion concentration ([Na+]) was regulated by voltage-gated sodium
channels (Nav). However, whether intracellular [Na+] is also involved
in mammalian organ regeneration is unknown, because of lacking suitable
mammalian models. Deer antlers are a novel model for studying
mammalian organ #morphogenesis. It is now well known that antlers
generate from #antlerogenicperiosteum (AP) and regenerate from pedicle
(antecedent of antler) periosteum (PP). Cells from the AP and PP have
stem cell attributes, thus termed antler stem cells. In the present
study,
the intracellular sodium ion of the cells from the AP, PP and facial
periosteum (FP) were strained in vitro with CoroNa Green indicator dye.
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