Abstract
#Resveratrol is a well notorious compound that may play a role in the
prevention of diabetes complications and different cancers. Along,
resveratrol, a naturally occurring #phytoalexin, is known to exert
numerous beneficial effects in the organism. Isolation of resveratrol
from
plants, however, has been proved being difficult. Importantly, the
bioavailability in the body is poor therefore capability is reduced and
not
enough resveratrol reaches the target organ. In this study we generated
different #methoxylated resveratrol analogues using Wittig reaction.
#transstilbene obtained was 0.08 g and the cis one was 0.01 g. Additionally with the Horner-Witting method a yield of 0.15 g trans
stilbene was
obtained. By substituting the hydroxyl group with methoxy group at
different positions on the aromatic rings, we could increase the
efficacy
and #bioavailability of the trans form of resveratrol.
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