Abstract
#Sertoli cells (SeC) are responsible for the #immunoprivileged status
of the testis thanks to which allogeneic or #xenogeneic engraftments of
testes can survive without any pharmacological immune suppression. This
peculiar SeC’s ability is dependent on their secretion of a plethora of
factors including maturative factors, hormones, growth factors,
cytokines and immunomodulatory factors. The #anti-inflammatory and
trophic properties of SeC have been largely exploited in several
experimental models of diseases, diabetes being the most
studied.#Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive
pathology in which lack of functional dystrophin leads to progressive
muscle degeneration culminating in loss of independent locomotion, and
premature death due to cardiac and respiratory failure.
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For more Biomedical Engineering Articles on BJSTR
Do Porcine Sertoli Cells Represent an Opportunity for #DuchenneMuscularDystrophy? by Guglielmo Sorci in BJSTR
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